Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes (Q44915348)

7 December 2017

title

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes (English)

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7 December 2017

1

Paul Dent

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7 December 2017

6

Sarah Spiegel

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7 December 2017

Youwen Fang

2

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7 December 2017

Seema Gupta

3

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7 December 2017

Elaine Studer

4

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7 December 2017

Clint Mitchell

5

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7 December 2017

Philip B Hylemon

7

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7 December 2017

language of work or name

English

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publication date

1 December 2005

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7 December 2017

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volume

42

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issue

6

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page(s)

1291-1299

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Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

7 December 2017

cites work

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Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes

21 January 2018

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Bile acids activate EGF receptor via a TGF-alpha-dependent mechanism in human cholangiocyte cell lines

21 January 2018

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Functional interaction of lithocholic acid conjugates with M3 muscarinic receptors on a human colon cancer cell line

21 January 2018

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The vagal nerve stimulates activation of the hepatic progenitor cell compartment via muscarinic acetylcholine receptor type 3.

21 January 2018

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Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes

21 January 2018

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Transcriptional regulation of alpha(1b) adrenergic receptors (alpha(1b)AR) by nuclear factor 1 (NF1): a decline in the concentration of NF1 correlates with the downregulation of alpha(1b)AR gene expression in regenerating liver

21 January 2018

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Bile salt transporters: molecular characterization, function, and regulation

21 January 2018

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Enterohepatic circulation: physiological, pharmacokinetic and clinical implications

21 January 2018

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7 January 2021

Modeling plasma lipoprotein-bile lipid relationships: differential impact of psyllium and cholestyramine in hamsters fed a lithogenic diet

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7 January 2021

Chronic cholestatic diseases

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7 January 2021

Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes

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7 January 2021

Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes

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7 January 2021

Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes

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7 January 2021

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

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7 January 2021

Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation

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7 January 2021

Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis

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7 January 2021

Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells

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7 January 2021

Effects of pertussis toxin on extracellular signal-regulated kinase activation in hepatocytes by hormones and receptor-independent agents: evidence suggesting a stimulatory role of G(i) proteins at a level distal to receptor coupling

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7 January 2021

Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells

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7 January 2021

Src-kinase-dependent epidermal growth factor receptor transactivation in salivary mucin secretion in response to beta-adrenergic G-protein-coupled receptor activation

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7 January 2021

Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2alpha in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive

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7 January 2021

Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation

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7 January 2021

G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases

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7 January 2021

Activation of muscarinic receptor signaling by bile acids: physiological and medical implications

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7 January 2021

A G protein-coupled receptor responsive to bile acids

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7 January 2021

Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist

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7 January 2021

Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3

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7 January 2021

Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.

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7 January 2021

Deoxycholic acid conjugates are muscarinic cholinergic receptor antagonists

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7 January 2021

Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes

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7 January 2021

SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells

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7 January 2021

Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes.

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7 January 2021

Liver cell lines for the study of hepatocyte functions and immunological response

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7 January 2021

Discovery of new G protein-coupled receptors for lipid mediators

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7 January 2021

A family of fatty acid binding receptors

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7 January 2021

Sphingosine-1-phosphate: an enigmatic signalling lipid

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7 January 2021

Identifiers

DOI

10.1002/HEP.20942

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7 December 2017

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