RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. (Q44964949)

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scientific article published on 4 July 2004

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English	RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.	scientific article published on 4 July 2004

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instance of

scholarly article

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Europe PubMed Central

PubMed publication ID

15235598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

title

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia (English)

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stated in

Europe PubMed Central

PubMed publication ID

15235598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

main subject

neurodegeneration

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inferred from title

author

Qinwen Mao

series ordinal

2

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stated in

Europe PubMed Central

PubMed publication ID

15235598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

Harry T. Orr

series ordinal

6

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Europe PubMed Central

PubMed publication ID

15235598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

author name string

Haibin Xia

series ordinal

1

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Europe PubMed Central

PubMed publication ID

15235598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

Steven L Eliason

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3

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Europe PubMed Central

PubMed publication ID

15235598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

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30 December 2019

Scott Q Harper

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4

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Europe PubMed Central

PubMed publication ID

15235598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

Inês H Martins

series ordinal

5

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Europe PubMed Central

PubMed publication ID

15235598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

Henry L Paulson

series ordinal

7

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Europe PubMed Central

PubMed publication ID

15235598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

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30 December 2019

Linda Yang

series ordinal

8

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Europe PubMed Central

PubMed publication ID

15235598

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30 December 2019

Robert M Kotin

series ordinal

9

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Europe PubMed Central

PubMed publication ID

15235598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

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30 December 2019

Beverly L Davidson

series ordinal

10

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Europe PubMed Central

PubMed publication ID

15235598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

language of work or name

English

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publication date

4 July 2004

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Europe PubMed Central

PubMed publication ID

15235598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

published in

Nature Medicine

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stated in

Europe PubMed Central

PubMed publication ID

15235598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

volume

10

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Europe PubMed Central

PubMed publication ID

15235598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

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30 December 2019

issue

8

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Europe PubMed Central

PubMed publication ID

15235598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

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30 December 2019

page(s)

816-820

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Europe PubMed Central

PubMed publication ID

15235598

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retrieved

30 December 2019

cites work

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.

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7 January 2021

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Spinocerebellar ataxia type 1

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Crossref

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https://api.crossref.org/works/10.1038%2FNM1076

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7 January 2021

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Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

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7 January 2021

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SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

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Crossref

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7 January 2021

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Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

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Crossref

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Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference

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Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.

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Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.

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Identifiers

DOI

10.1038/NM1076

1 reference

stated in

Europe PubMed Central

PubMed publication ID

15235598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

PubMed publication ID

15235598

1 reference

stated in

Europe PubMed Central

PubMed publication ID

15235598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15235598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

30 December 2019

ResearchGate publication ID

8472559

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