Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis (Q45161628)

10 December 2017

title

Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis (English)

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10 December 2017

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Marcela Brissova

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10 December 2017

Michael Blaha

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10 December 2017

Cathi Spear

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10 December 2017

Wendell Nicholson

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Aramandla Radhika

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10 December 2017

Masakazu Shiota

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10 December 2017

Maureen J Charron

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10 December 2017

Christopher V E Wright

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10 December 2017

Alvin C Powers

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10 December 2017

publication date

23 November 2004

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American Journal of Physiology - Endocrinology and Metabolism

10 December 2017

published in

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10 December 2017

volume

288

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10 December 2017

issue

4

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10 December 2017

page(s)

E707-14

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beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

10 December 2017

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Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

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PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

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The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells

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Pdx-1 enables insulin secretion by regulating synaptotagmin 1 gene expression

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Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor

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The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter

21 January 2018

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PDX-1 mediates glucose responsiveness of GAD(67), but not GAD(65), gene transcription in islets of Langerhans

21 January 2018

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Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

21 January 2018

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21 January 2018

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Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2.

21 January 2018

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21 January 2018

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21 January 2018

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Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300

21 January 2018

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GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

21 January 2018

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Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas

21 January 2018

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Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression

21 January 2018

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Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.

21 January 2018

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Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1.

21 January 2018

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Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription

21 January 2018

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The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells

21 January 2018

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IRS proteins and the common path to diabetes

21 January 2018

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Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

21 January 2018

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21 January 2018

Identifiers

DOI

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10 December 2017

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