Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression (Q45215121)

10 December 2017

title

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression (English)

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10 December 2017

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5

Sarah Spiegel

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10 December 2017

Meryem Bektas

1

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10 December 2017

Puneet S Jolly

2

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10 December 2017

Carola Müller

3

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10 December 2017

Jürgen Eberle

4

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10 December 2017

Christoph C Geilen

6

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10 December 2017

language of work or name

English

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publication date

1 January 2005

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10 December 2017

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10 December 2017

volume

24

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10 December 2017

issue

1

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10 December 2017

page(s)

178-187

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Decreased proliferation of human melanoma cell lines caused by antisense RNA against translation factor eIF-4A1.

10 December 2017

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Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma

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Ceramide: role in growth inhibitory cascades

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PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

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Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

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Glycosylation of ceramide potentiates cellular resistance to tumor necrosis factor-alpha-induced apoptosis

21 January 2018

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Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

21 January 2018

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Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors

21 January 2018

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TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes

21 January 2018

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Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase

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The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis

21 January 2018

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Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death

21 January 2018

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Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

21 January 2018

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Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis

21 January 2018

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Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine

21 January 2018

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Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells

21 January 2018

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Bcl-2 interrupts the ceramide-mediated pathway of cell death.

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Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

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7 January 2021

Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity

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7 January 2021

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

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7 January 2021

Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation

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7 January 2021

Ceramide-mediated clustering is required for CD95-DISC formation

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7 January 2021

Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma

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7 January 2021

Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

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7 January 2021

The CD95(APO-1/Fas) DISC and beyond

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7 January 2021

bcl-2 over-expression enhances NF-kappaB activity and induces mmp-9 transcription in human MCF7(ADR) breast-cancer cells

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7 January 2021

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

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7 January 2021

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

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7 January 2021

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208019

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Dimensions Publication ID

10 December 2017

1004923025

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