Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models (Q45248999)

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scientific article published in June 2005

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English	Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models	scientific article published in June 2005

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 December 2017

Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models (English)

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Europe PubMed Central

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11 December 2017

Alzheimer's disease

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Sally A Frautschy

7

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Sally A Frautschy

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11 December 2017

author name string

Takashi Morihara

1

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11 December 2017

Bruce Teter

2

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11 December 2017

Fusheng Yang

3

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11 December 2017

Giselle P Lim

4

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11 December 2017

Sally Boudinot

5

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11 December 2017

F Douglas Boudinot

6

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11 December 2017

Greg M Cole

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11 December 2017

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publication date

1 June 2005

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11 December 2017

Neuropsychopharmacology

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11 December 2017

30

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PubMed publication ID

11 December 2017

6

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Europe PubMed Central

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11 December 2017

1111-1120

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Europe PubMed Central

PubMed publication ID

11 December 2017

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1 reference

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Inflammation and Alzheimer's disease

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Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition

1 reference

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Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.

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A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

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21 January 2018

Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1.

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Clinical pharmacokinetics of ibuprofen. The first 30 years

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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

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Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease

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Estimation of the in vivo effect of cyclooxygenase inhibitors on prostaglandin E2 levels in mouse brain

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Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology

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Dynamics of cellular entry and drug delivery by dendritic polymers into human lung epithelial carcinoma cells

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Developmental expression of alpha 1-antichymotrypsin in brain may be related to astrogliosis.

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A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease.

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Distortion of allelic expression of apolipoprotein E in Alzheimer's disease.

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Transforming growth factor-beta 1 induces neuronal and astrocyte genes: tubulin alpha 1, glial fibrillary acidic protein and clusterin

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Glial fibrillary acidic protein: regulation by hormones, cytokines, and growth factors

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Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype

1 reference

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Serum alpha 1-antichymotrypsin level as a marker for Alzheimer-type dementia.

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21 January 2018

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

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Regulation of macrophage eicosanoid generation is dependent on nuclear factor kappaB.

1 reference

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

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Double placebo design in a prevention trial for Alzheimer's disease.

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Alpha 1-antichymotrypsin as a possible biochemical marker for Alzheimer-type dementia

1 reference

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Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

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Inflammatory processes in Alzheimer's disease

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Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

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Selective inhibition of Abeta42 production by NSAID R-enantiomers

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Interleukin-1 and the immunogenetics of Alzheimer disease

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Interleukin-1, neuroinflammation, and Alzheimer's disease

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Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice

1 reference

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21 January 2018

Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E

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Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

1 reference

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Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse

1 reference

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Cyclooxygenase (COX)-2 and COX-1 Potentiate β-Amyloid Peptide Generation through Mechanisms That Involve γ-Secretase Activity

1 reference

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21 January 2018

Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease

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21 January 2018

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

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21 January 2018

The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.

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21 January 2018

The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production

1 reference

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Differential regulation of astrocytic mRNAs in the rat striatum after lesions of the cortex or substantia nigra

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21 January 2018

Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE.

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21 January 2018

Risk of Alzheimer's disease and duration of NSAID use.

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Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

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Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen

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Distribution of plasma alpha 1-antichymotrypsin levels in Alzheimer disease patients and controls and their genetic controls.

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21 January 2018

Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's disease

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

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21 January 2018

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

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Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology

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21 January 2018

Apolipoprotein E mRNA in the brains of patients with Alzheimer's disease.

1 reference

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Up-regulated production and activation of the complement system in Alzheimer's disease brain

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Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study

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Increased apolipoprotein E mRNA in the hippocampus in Alzheimer disease and in rats after entorhinal cortex lesioning

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Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

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Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

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Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1 reference

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Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes

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Regulation of cytokine secretion and amyloid precursor protein processing by proinflammatory amyloid beta (A beta).

1 reference

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7 January 2021

based on heuristic

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Alpha 1-antichymotrypsin level in cerebrospinal fluid is closely associated with late onset Alzheimer's disease.

1 reference

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7 January 2021

based on heuristic

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Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

1 reference

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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

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7 January 2021

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Mechanism of interleukin-1- and tumor necrosis factor alpha-dependent regulation of the alpha 1-antichymotrypsin gene in human astrocytes

1 reference

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7 January 2021

based on heuristic

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The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.NPP.1300668

7 January 2021

based on heuristic

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Acute phase reactant alpha 1-antichymotrypsin is increased in cerebrospinal fluid and serum of patients with probable Alzheimer disease.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Gene polymorphism affecting α1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk

1 reference

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7 January 2021

based on heuristic

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Interleukin-1 beta and tumor necrosis factor-alpha induce expression of alpha 1-antichymotrypsin in human astrocytoma cells by activation of nuclear factor-kappa B.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease.

1 reference

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7 January 2021

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inferred from DOI database lookup

Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.

1 reference

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7 January 2021

based on heuristic

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Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

1 reference

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based on heuristic

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Synthesis of apolipoprotein E (ApoE) mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE

1 reference

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7 January 2021

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Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1038/SJ.NPP.1300668

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

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