Suppression of tumor growth through disruption of hypoxia-inducible transcription (Q45872806)

17 December 2017

title

Suppression of tumor growth through disruption of hypoxia-inducible transcription (English)

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17 December 2017

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1

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17 December 2017

William G. Kaelin

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4

object named as

W G Kaelin

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17 December 2017

S Wang

2

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17 December 2017

J M Klco

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3

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D M Livingston

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5

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17 December 2017

language of work or name

English

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publication date

1 December 2000

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17 December 2017

published in

Nature Medicine

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17 December 2017

volume

6

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issue

12

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17 December 2017

page(s)

1335-1340

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Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

cites work

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7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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7 January 2021

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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7 January 2021

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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7 January 2021

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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7 January 2021

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

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7 January 2021

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

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7 January 2021

An essential role for p300/CBP in the cellular response to hypoxia

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7 January 2021

Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

1 reference

7 January 2021

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

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7 January 2021

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

1 reference

7 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

7 January 2021

Measurement of Human Tumour Oxygenation Status by a Polarographic Needle Electrode: An analysis of inter- and intratumour heterogeneity

1 reference

7 January 2021

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

1 reference

7 January 2021

Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies

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7 January 2021

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

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7 January 2021

SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells

1 reference

7 January 2021

An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer

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7 January 2021

Development of a hypoxia-responsive vector for tumor-specific gene therapy

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7 January 2021

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

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7 January 2021

Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition.

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7 January 2021

Role of CBP/P300 in nuclear receptor signalling

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7 January 2021

SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein

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7 January 2021

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

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7 January 2021

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha

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7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

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7 January 2021

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors

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7 January 2021

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.

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7 January 2021

Pharmacological rescue of mutant p53 conformation and function

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7 January 2021

Tumor induction of VEGF promoter activity in stromal cells

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7 January 2021

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

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7 January 2021

Identifiers

DOI

10.1038/82146

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17 December 2017

Dimensions Publication ID

1027986752

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17 December 2017