The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. (Q45936344)

18 December 2017

title

The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. (English)

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18 December 2017

3

William G Dunphy

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18 December 2017

author name string

Joon Lee

series ordinal

1

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18 December 2017

Akiko Kumagai

series ordinal

2

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18 December 2017

language of work or name

English

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publication date

18 July 2007

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18 December 2017

Journal of Biological Chemistry

published in

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18 December 2017

volume

282

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18 December 2017

issue

38

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18 December 2017

page(s)

28036-28044

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18 December 2017

Cell cycle checkpoint signaling through the ATM and ATR kinases

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TopBP1 activates the ATR-ATRIP complex

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Human claspin is required for replication checkpoint control

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Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.

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Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

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Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

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Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA

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Replication protein A-mediated recruitment and activation of Rad17 complexes

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Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctions

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Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.

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Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling.

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The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts

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21 January 2018

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Positive regulation of Wee1 by Chk1 and 14-3-3 proteins

21 January 2018

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Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin

21 January 2018

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21 January 2018

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Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

21 January 2018

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BRCT domain-containing protein TopBP1 functions in DNA replication and damage response

21 January 2018

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One-thousand-and-one substrates of protein kinase CK2?

21 January 2018

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The structural determinants of checkpoint activation

21 January 2018

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

21 January 2018

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The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M704635200

1 reference

18 December 2017

release_gnhsya3hh5gore3th6dlmscm2a

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gnhsya3hh5gore3th6dlmscm2a

mapped directly with Wikidata item

24 November 2022

based on heuristic

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18 December 2017