Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. (Q45954200)

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title

Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model (English)

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Agostino Palmeri

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Ottavio Arancio

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Lucia Privitera

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Elena Leznik

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Agnieszka Staniszewski

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object named as

Agnieszka Staniszewski

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author name string

Shi Xian Deng

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Shumin Liu

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Hong Zhang

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Yan Feng

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Donald W Landry

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language of work or name

English

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publication date

1 June 2009

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published in

Journal of Neuroscience

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volume

29

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issue

25

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page(s)

8075-8086

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Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

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cites work

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Alzheimer's disease is a synaptic failure

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Cellular memory and the histone code

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Mechanisms of peripheral microvascular dysfunction in transgenic mice overexpressing the Alzheimer's disease amyloid Abeta protein

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Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism

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Targeting the CREB pathway for memory enhancers

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Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects

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The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 1: 5,6,11,11a-Tetrahydro-1H-imidazo[1‘,5‘:1,6]pyrido[3,4-b]indole-1,3(2H)-dione Analogues

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The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1‘,2‘:1,6]pyrido[3,4-b]indole-1,4-dione Analogues

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CSF markers for Alzheimer's disease: Total tau, phospho-tau and Aβ42

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mRNA expression patterns of the cGMP‐hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain

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Species differences in the localization of cGMP-producing and NO-responsive elements in the mouse and rat hippocampus using cGMP immunocytochemistry.

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Aging enhances vascular dysfunction induced by the Alzheimer's peptide beta-amyloid

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Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice

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Soluble beta-amyloid (A beta) 40 causes attenuation or potentiation of noradrenaline-induced vasoconstriction in rats depending upon the concentration employed

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Phosphodiesterase type 5 inhibition improves early memory consolidation of object information

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Mechanisms of soluble beta-amyloid impairment of endothelial function

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Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

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The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis

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Novel nitrates as NO mimetics directed at Alzheimer's disease.

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Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism

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Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

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Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity.

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Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors.

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Vascular factors in Alzheimer's disease

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Case report: Avoidance of palpable corporal fibrosis due to priapism with upregulators of nitric oxide

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Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester

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Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism

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NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease

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Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

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Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease.

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Pharmacology of nootropics and metabolically active compounds in relation to their use in dementia

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Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions

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12 December 2020

Phosphodiesterase inhibitors facilitate memory for passive avoidance conditioning

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12 December 2020

Brain cyclic AMP and memory in mice

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12 December 2020

Mechanisms of synaptic dysfunction in Alzheimer's disease

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12 December 2020

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12 December 2020

[Blood pressure and Alzheimer's disease]

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12 December 2020

10.1523/JNEUROSCI.0864-09.2009

Identifiers

DOI

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PubMed publication ID

19553447

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