Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. (Q45952803)

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5 November 2019

title

Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1 (English)

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5 November 2019

1

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5 November 2019

Ariane Abrieu

2

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5 November 2019

Don W. Cleveland

3

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5 November 2019

author name string

Yinghui Mao

1

1 reference

18 December 2017

http://europepmc.org/abstract/MED/12859900

Ariane Abrieu

2

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18 December 2017

http://europepmc.org/abstract/MED/12859900

Don W Cleveland

3

1 reference

18 December 2017

http://europepmc.org/abstract/MED/12859900

language of work or name

English

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publication date

1 July 2003

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5 November 2019

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5 November 2019

volume

114

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5 November 2019

issue

1

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5 November 2019

page(s)

87-98

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CENP-E as an essential component of the mitotic checkpoint in vitro.

5 November 2019

cites work

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Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.

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Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis.

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7 January 2021

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

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7 January 2021

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

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7 January 2021

BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1.

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7 January 2021

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

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Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores

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Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p

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Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

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7 January 2021

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

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Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint

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Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

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Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast

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7 January 2021

MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p

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7 January 2021

Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells

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The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells

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7 January 2021

Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events

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7 January 2021

Identification of a human mitotic checkpoint gene: hsMAD2

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7 January 2021

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

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7 January 2021

Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E

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7 January 2021

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

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7 January 2021

The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase

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7 January 2021

CENP-E function at kinetochores is essential for chromosome alignment.

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7 January 2021

Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity

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7 January 2021

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

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7 January 2021

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

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7 January 2021

Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

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7 January 2021

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

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7 January 2021

The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

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7 January 2021

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7 January 2021

The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint

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7 January 2021

CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

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7 January 2021

p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase

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7 January 2021

Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint

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7 January 2021

CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

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7 January 2021

CENP-E is a putative kinetochore motor that accumulates just before mitosis

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Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12859900%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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