Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli. (Q45981746)

18 December 2017

title

Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli. (English)

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18 December 2017

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Amber C Donahue

1

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18 December 2017

David A Fruman

series ordinal

2

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18 December 2017

language of work or name

English

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publication date

1 October 2007

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18 December 2017

European Journal of Immunology

published in

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18 December 2017

volume

37

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18 December 2017

issue

10

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18 December 2017

page(s)

2923-2936

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18 December 2017

Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activation

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Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation

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Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation

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Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development

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Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry

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Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway

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TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression

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Development and selection of marginal zone B cells

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Models for peripheral B cell development and homeostasis.

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Marginal zone B cells in lymphocyte activation and regulation

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7 January 2021

Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells.

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7 January 2021

Mouse follicular and marginal zone B cells show differential expression of Dnmt3a and sensitivity to 5'-azacytidine.

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7 January 2021

Identification of CD36 as a new surface marker of marginal zone B cells by transcriptomic analysis.

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7 January 2021

PI3K signaling controls cell fate at many points in B lymphocyte development and activation

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7 January 2021

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

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7 January 2021

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

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7 January 2021

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

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7 January 2021

Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha

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7 January 2021

Frontline: The p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses.

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Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

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PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction

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Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

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7 January 2021

Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin

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7 January 2021

Suppression of B cell activation by cyclosporin A, FK506 and rapamycin

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7 January 2021

PI3-kinase and TOR: PIKTORing cell growth

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7 January 2021

TOR signaling in growth and metabolism

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7 January 2021

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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7 January 2021

Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum.

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7 January 2021

The p110delta subunit of phosphoinositide 3-kinase is required for the lipopolysaccharide response of mouse B cells.

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Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway

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7 January 2021

B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Characterization of marginal zone B cell precursors

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Convergence of signaling pathways on the activation of ERK in B cells

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Characterization of the murine immunological signaling network with phosphospecific flow cytometry

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Phospho-proteomic immune analysis by flow cytometry: from mechanism to translational medicine at the single-cell level

1 reference

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7 January 2021

Measuring phosphorylated Akt and other phosphoinositide 3-kinase-regulated phosphoproteins in primary lymphocytes.

1 reference

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7 January 2021

Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Activation of the PKB/AKT pathway by ICAM-2.

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

The amino acid sensitive TOR pathway from yeast to mammals.

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Antigen-receptor cross-linking and lipopolysaccharide trigger distinct phosphoinositide 3-kinase-dependent pathways to NF-kappa B activation in primary B cells

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

IRF3 mediates a TLR3/TLR4-specific antiviral gene program

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation.

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https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Vav proteins are required for B-lymphocyte responses to LPS

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Marginal zones: the major B cell compartment of rat spleens

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Signaling roles of diacylglycerol kinases

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

PI3K and negative regulation of TLR signaling.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Bacterial lipopolysaccharide induced B cell activation is mediated via a phosphatidylinositol 3-kinase dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Xid-like phenotypes: a B cell signalosome takes shape

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200737281

7 January 2021

Identifiers

DOI

10.1002/EJI.200737281

1 reference

18 December 2017

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18 December 2017