Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells (Q46486969)

22 December 2017

title

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells (English)

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22 December 2017

author name string

Bollag G

1

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22 December 2017

Clapp DW

2

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22 December 2017

Shih S

3

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22 December 2017

Adler F

4

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22 December 2017

Zhang YY

5

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22 December 2017

Thompson P

6

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22 December 2017

Lange BJ

7

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22 December 2017

Freedman MH

8

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22 December 2017

McCormick F

9

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22 December 2017

Jacks T

10

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22 December 2017

Shannon K

11

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22 December 2017

language of work or name

English

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publication date

1 February 1996

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22 December 2017

published in

Nature Genetics

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22 December 2017

volume

12

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22 December 2017

issue

2

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22 December 2017

page(s)

144-148

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22 December 2017

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

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Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function

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Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

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7 January 2021

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Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis

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Loss of NF1 alleles in phaeochromocytomas from patients with type I neurofibromatosis

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Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras

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7 January 2021

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

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7 January 2021

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

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7 January 2021

Central role of tumour necrosis factor, GM‐CSF, and interleukin 1 in the pathogenesis of juvenile chronic myelogenous leukaemia

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7 January 2021

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

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7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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7 January 2021

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity

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7 January 2021

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

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7 January 2021

Identifiers

DOI

10.1038/NG0296-144

1 reference

22 December 2017

1 reference

22 December 2017