Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance (Q46507502)

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scientific article published in July 2008

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English	Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance	scientific article published in July 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593850

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance (English)

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593850

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based on heuristic

inferred from title

insulin resistance

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based on heuristic

inferred from title

2

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593850

Ralph A. DeFronzo

14

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Ralph A DeFronzo

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22 December 2017

Holly Van Remmen

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Holly Van Remmen

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Europe PubMed Central

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22 December 2017

author name string

Muhammad A Abdul-Ghani

1

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22 December 2017

http://europepmc.org/abstract/MED/18593850

Yuhong Liu

3

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22 December 2017

http://europepmc.org/abstract/MED/18593850

Alberto O Chavez

4

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22 December 2017

http://europepmc.org/abstract/MED/18593850

Bogdan Balas

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22 December 2017

http://europepmc.org/abstract/MED/18593850

Pengou Zuo

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22 December 2017

http://europepmc.org/abstract/MED/18593850

Zhi Chang

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22 December 2017

http://europepmc.org/abstract/MED/18593850

Devjit Tripathy

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22 December 2017

http://europepmc.org/abstract/MED/18593850

Rucha Jani

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22 December 2017

http://europepmc.org/abstract/MED/18593850

Marjorie Molina-Carrion

10

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22 December 2017

http://europepmc.org/abstract/MED/18593850

Adriana Monroy

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22 December 2017

http://europepmc.org/abstract/MED/18593850

Franco Folli

12

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22 December 2017

http://europepmc.org/abstract/MED/18593850

publication date

1 July 2008

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22 December 2017

http://europepmc.org/abstract/MED/18593850

American Journal of Physiology - Endocrinology and Metabolism

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22 December 2017

http://europepmc.org/abstract/MED/18593850

295

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http://europepmc.org/abstract/MED/18593850

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http://europepmc.org/abstract/MED/18593850

E678-85

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22 December 2017

http://europepmc.org/abstract/MED/18593850

Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Metabolic and molecular basis of insulin resistance

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes

1 reference

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21 January 2018

Dose-response effect of elevated plasma free fatty acid on insulin signaling

1 reference

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21 January 2018

Mitochondrial energy dissipation by fatty acids. Mechanisms and implications for cell death

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

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Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

1 reference

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Pathogenesis of type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle.

1 reference

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21 January 2018

Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Burning fat: the structural basis of fatty acid beta-oxidation

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Inhibitory effect of palmitate on the mitochondrial NADH:ubiquinone oxidoreductase (complex I) as related to the active-de-active enzyme transition

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Mitochondrial dysfunction and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Complex III releases superoxide to both sides of the inner mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Skeletal muscle triglyceride levels are inversely related to insulin action.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Muscle triglycerides and mitochondrial function: possible mechanisms for the development of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Palmitic acid opens a novel cyclosporin A-insensitive pore in the inner mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90287.2008

21 January 2018

Free fatty acid effects on mitochondrial permeability: an overview

1 reference

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Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

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21 January 2018

Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle

1 reference

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Biochemical and Osmotic Properties of Skeletal Muscle Mitochondria

1 reference

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21 January 2018

Identifiers

10.1152/AJPENDO.90287.2008

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593850

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18593850

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