FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model. (Q46664432)

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5 January 2020

title

FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model (English)

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5 January 2020

2

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Brian Huntly

9

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5 January 2020

author name string

Benjamin H Lee

1

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5 January 2020

Ema Anastasiadou

3

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5 January 2020

Christina L Boulton

4

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5 January 2020

Sarah W Joseph

5

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5 January 2020

Sonia M Amaral

6

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5 January 2020

David P Curley

7

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5 January 2020

Nicole Duclos

8

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5 January 2020

Doriano Fabbro

10

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5 January 2020

James D Griffin

11

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5 January 2020

Dwight Gary Gilliland

12

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language of work or name

English

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publication date

1 November 2005

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volume

24

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issue

53

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5 January 2020

page(s)

7882-7892

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PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder

5 January 2020

cites work

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Point mutations in the FLT3 gene in AML.

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Genomic structure of human FLT3: implications for mutational analysis

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Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification

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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

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7 January 2021

PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease.

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7 January 2021

Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues.

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7 January 2021

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

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7 January 2021

The roles of FLT3 in hematopoiesis and leukemia

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7 January 2021

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

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7 January 2021

Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia

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7 January 2021

High expression but no internal tandem duplication of FLT3 in normal hematopoietic cells

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7 January 2021

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

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7 January 2021

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

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7 January 2021

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

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7 January 2021

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

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7 January 2021

Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation.

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7 January 2021

Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

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7 January 2021

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

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7 January 2021