FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A. (Q46832201)

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scientific article published in December 2007

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English	FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.	scientific article published in December 2007

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scholarly article

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Europe PubMed Central

PubMed publication ID

18160642

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25 December 2017

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http://europepmc.org/abstract/MED/18160642

title

FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A. (English)

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Europe PubMed Central

PubMed publication ID

18160642

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25 December 2017

reference URL

http://europepmc.org/abstract/MED/18160642

main subject

phosphorylation

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Stephanie Ceman

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5

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Stephanie Ceman

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PMC publication ID

6673448

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Stephen T. Warren

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Stephen T Warren

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PMC publication ID

6673448

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Mika Nakamoto

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Mika Nakamoto

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6673448

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Usha Narayanan

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Usha Narayanan

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PMC publication ID

6673448

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author name string

Vijayalaxmi Nalavadi

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2

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PMC publication ID

6673448

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David C Pallas

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4

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6673448

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Gary J Bassell

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6

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PMC publication ID

6673448

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English

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publication date

1 December 2007

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PubMed publication ID

18160642

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25 December 2017

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http://europepmc.org/abstract/MED/18160642

published in

Journal of Neuroscience

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Europe PubMed Central

PMC publication ID

6673448

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volume

27

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PMC publication ID

6673448

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16 May 2020

issue

52

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Europe PubMed Central

PMC publication ID

6673448

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16 May 2020

page(s)

14349-14357

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6673448

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cites work

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

Functional expression of human PP2Ac in yeast permits the identification of novel C-terminal and dominant-negative mutant forms

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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Metabotropic glutamate receptors trigger homosynaptic protein synthesis to prolong long-term potentiation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that fragile X mental retardation protein is a negative regulator of translation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

Extrasomatic targeting of MAP2, vasopressin and oxytocin mRNAs in mammalian neurons

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

Roles of serine/threonine phosphatases in hippocampal synaptic plasticity.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

Protein phosphatase 2A: variety of forms and diversity of functions

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Okadaic acid: the archetypal serine/threonine protein phosphatase inhibitor

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Methylation of the arginine-glycine-rich region in the fragile X mental retardation protein FMRP differentially affects RNA binding.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation influences the translation state of FMRP-associated polyribosomes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

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inferred from PubMed ID database lookup

The mGluR theory of fragile X mental retardation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-translational protein modification as the substrate for long-lasting memory

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory amino acid uptake and N-methyl-D-aspartate-mediated secretion in a neural cell line

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RAS Signalling Is Abnormal in a c-raf1 MEK1 Double Mutant

1 reference

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https://pubmed.ncbi.nlm.nih.gov/18160642

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeability characteristics of erythrocyte membrane to okadaic acid and calyculin A

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of monoamine metabolism in oxidative glutamate toxicity.

1 reference

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress.

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reference URL

https://pubmed.ncbi.nlm.nih.gov/18160642

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

DOI

10.1523/JNEUROSCI.2969-07.2007

1 reference

stated in

Europe PubMed Central

PMC publication ID

6673448

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673448&resulttype=core&format=json

retrieved

16 May 2020

PMC publication ID

6673448

1 reference

stated in

Europe PubMed Central

PMC publication ID

6673448

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673448&resulttype=core&format=json

retrieved

16 May 2020

PubMed publication ID

18160642

1 reference

stated in

Europe PubMed Central

PMC publication ID

6673448

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673448&resulttype=core&format=json

retrieved

16 May 2020

 

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