PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding (Q47705794)

5 February 2018

title

PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding (English)

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5 February 2018

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4

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author name string

Francesca Moretti

series ordinal

1

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Constanze Kaiser

series ordinal

2

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Agnieszka Zdanowicz-Specht

series ordinal

3

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publication date

27 May 2012

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Nature Structural & Molecular Biology

published in

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volume

19

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issue

6

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page(s)

603-608

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Gene silencing by microRNAs: contributions of translational repression and mRNA decay

21 January 2018

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The mRNA closed-loop model: the function of PABP and PABP-interacting proteins in mRNA translation

21 January 2018

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Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

21 January 2018

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Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.

21 January 2018

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The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release

21 January 2018

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Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

21 January 2018

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Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

21 January 2018

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Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein

21 January 2018

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The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing

21 January 2018

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GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets

21 January 2018

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Deadenylation is a widespread effect of miRNA regulation

21 January 2018

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PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro

21 January 2018

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MicroRNAs direct rapid deadenylation of mRNA

21 January 2018

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Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression

21 January 2018

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Drosophila argonaute1 and argonaute2 employ distinct mechanisms for translational repression.

21 January 2018

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microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells

21 January 2018

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Activation of a microRNA response in trans reveals a new role for poly(A) in translational repression

21 January 2018

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Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development.

21 January 2018

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Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms

21 January 2018

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Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation.

21 January 2018

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A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

21 January 2018

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Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame

21 January 2018

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MicroRNAs: target recognition and regulatory functions

21 January 2018

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The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing

21 January 2018

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Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila

21 January 2018

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Structural variety of arginine-rich RNA-binding peptides

21 January 2018

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Sorting of Drosophila small silencing RNAs

21 January 2018

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Identification of Drosophila MicroRNA targets

21 January 2018

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miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs

21 January 2018

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A specific role for the C-terminal region of the Poly(A)-binding protein in mRNA decay

21 January 2018

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Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae

21 January 2018

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miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

21 January 2018

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HuR recruits let-7/RISC to repress c-Myc expression

21 January 2018

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A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA

21 January 2018

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Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail.

21 January 2018

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Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis

21 January 2018

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Depletion of cellular poly (A) binding protein prevents protein synthesis and leads to apoptosis in HeLa cells

21 January 2018

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An efficient system for cap- and poly(A)-dependent translation in vitro

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22635249

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.2309

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5 February 2018

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5 February 2018