X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence (Q47774964)

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scientific article published in January 2003

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English	X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence	scientific article published in January 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

mutational analysis

1 reference

based on heuristic

inferred from title

5

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

author name string

G D King

1

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

R G Perez

2

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

M L Steinhilb

3

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

J R Gaut

4

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

language of work or name

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publication date

1 January 2003

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

120

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

1

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

143-154

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

It all sticks together--the APP-related family of proteins and Alzheimer's disease

1 reference

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Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms

1 reference

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7 January 2021

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Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid [...]

1 reference

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7 January 2021

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Molecular analysis of the X11-mLin-2/CASK complex in brain

1 reference

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7 January 2021

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The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

1 reference

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Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting

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The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

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A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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Increased generation of alternatively cleaved beta-amyloid peptides in cells expressing mutants of the amyloid precursor protein defective in endocytosis

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The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

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hFE65L influences amyloid precursor protein maturation and secretion

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7 January 2021

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Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

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7 January 2021

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Expression and characterization of the Drosophila X11-like/Mint protein during neural development

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7 January 2021

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A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission

1 reference

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7 January 2021

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The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

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7 January 2021

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Interaction of rat lin-10 with brain-enriched F-actin-binding protein, neurabin-II/spinophilin

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7 January 2021

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Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

1 reference

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7 January 2021

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

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7 January 2021

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Signal-dependent trafficking of beta-amyloid precursor protein-transferrin receptor chimeras in madin-darby canine kidney cells

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X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains

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7 January 2021

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c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

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Association of neuronal calcium channels with modular adaptor proteins

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The Fe65 and X11 families of proteins: proteins that interact with the Alzheimer's disease amyloid precursor protein.

1 reference

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7 January 2021

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The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity

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Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.

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Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2

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Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.

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Ligand-dependent G protein coupling function of amyloid transmembrane precursor

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Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

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Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways

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Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.

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Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

1 reference

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7 January 2021

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X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

1 reference

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7 January 2021

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Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

1 reference

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The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase

1 reference

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1 reference

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7 January 2021

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Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein

1 reference

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7 January 2021

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X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein

1 reference

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7 January 2021

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Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

1 reference

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7 January 2021

based on heuristic

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A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site.

1 reference

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7 January 2021

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Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

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1 reference

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1 reference

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10.1016/S0306-4522(03)00284-7

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Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

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24 November 2022

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PubMed publication ID

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Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/12849748

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