Design, synthesis and pharmacological evaluation of indolylsulfonamide amines as potent and selective 5-HT6 receptor antagonists (Q47786351)

5 February 2018

title

Design, synthesis and pharmacological evaluation of indolylsulfonamide amines as potent and selective 5-HT6 receptor antagonists (English)

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5 February 2018

author name string

Ramakrishna V S Nirogi

1

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Thrinath Reddy Bandyala

2

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Veena Reballi

3

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Jagadishu Babu Konda

4

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Anand V Daulatabad

5

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Mukkanti Khagga

6

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publication date

25 March 2014

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Journal of Enzyme Inhibition and Medicinal Chemistry

published in

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volume

30

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issue

1

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page(s)

85-97

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Molecular, pharmacological and functional diversity of 5-HT receptors

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Novel polymorphism in the 5'-upstream region of the human 5-HT6 receptor gene and schizophrenia

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5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585.

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Association study of the 5-HT(6) receptor polymorphism (C267T) and symptomatology and antidepressant response in major depressive disorders

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Association of the 5-HT6 receptor gene polymorphism C267T with Parkinson's disease

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Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease

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Association analysis of the 5-HT6 receptor polymorphism C267T with depression in patients with Alzheimer's disease

21 January 2018

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Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease

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Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

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Medicinal chemistry strategies to 5-HT(6) receptor ligands as potential cognitive enhancers and antiobesity agents

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Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.

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2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors

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New serotonin 5-HT(6) ligands from common feature pharmacophore hypotheses

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Synthesis and structure-activity relationship of novel conformationally restricted analogues of serotonin as 5-HT6 receptor ligands

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Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-НТ6 receptors.

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Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.

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(3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: potent and selective antagonists of the serotonin 5-HT6 receptor

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Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists.

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A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

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Characterization of [(125)I]-SB-258585 binding to human recombinant and native 5-HT(6) receptors in rat, pig and human brain tissue

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Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors

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Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies

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Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors

21 January 2018

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Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders

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Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop

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Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways

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10.3109/14756366.2014.889126

21 January 2018

Identifiers

DOI

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5 February 2018

release_y3hh7wsbkved3orzh4npzcfrie

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/y3hh7wsbkved3orzh4npzcfrie

mapped directly with Wikidata item

24 November 2022

based on heuristic

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5 February 2018