Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia (Q48144169)

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English	Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17554006

Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia (English)

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17554006

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cerebral infarction

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based on heuristic

inferred from title

Randall S. Johnson

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672155&resulttype=core&format=json

16 May 2020

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Oxana Baranova

1

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16 May 2020

Luis F Miranda

2

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16 May 2020

Paola Pichiule

3

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16 May 2020

Ioannis Dragatsis

4

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16 May 2020

Juan C Chavez

6

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16 May 2020

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publication date

1 June 2007

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17554006

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672155&resulttype=core&format=json

16 May 2020

27

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16 May 2020

23

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16 May 2020

6320-6332

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16 May 2020

Pathobiology of ischaemic stroke: an integrated view

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https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

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inferred from PubMed ID database lookup

Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, [...]

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https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain

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https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain

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https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain

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https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

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Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion

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https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

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Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia

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https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple molecular penumbras after focal cerebral ischemia

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https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of vascular endothelial growth factor and hypoxia-inducible factor-1alpha by global ischemia in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of hypoxia-inducible factor-1alpha in the brain of rats during chronic hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of cerebral tumor necrosis factor-alpha production during human ischemic stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of Tie-1 and Tie-2 receptor protein expression after cerebral ischemia-reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription. Oxygen sensing gets a second wind

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 is a neuronal target gene of NF-kappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor-kappaB contributes to infarction after permanent focal ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIF1 and oxygen sensing in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoprotective efficacy and mechanisms of the liposoluble iron chelator 2,2'-dipyridyl in the rat photothrombotic ischemic stroke model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxic preconditioning protects against ischemic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia preconditioning in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic cell death progression after photothrombotic focal cerebral ischaemia: effects of the lipophilic iron chelator 2,2'-dipyridyl.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral preconditioning and ischaemic tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of hypoxia-inducible factor 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional analysis of hypoxia-inducible factor 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 is induced globally in infarcted human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generalized lacZ expression with the ROSA26 Cre reporter strain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554006

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0449-07.2007

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672155&resulttype=core&format=json

16 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672155&resulttype=core&format=json

16 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672155&resulttype=core&format=json

16 May 2020

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