Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis (Q48160439)

9 February 2018

title

Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis (English)

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author name string

Tan J

1

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Town T

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Paris D

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Placzek A

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Parker T

5

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Crawford F

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Yu H

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Humphrey J

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publication date

1 June 1999

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Journal of Neuroimmunology

published in

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volume

97

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issue

1-2

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page(s)

77-85

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Molecular and biological characterization of a murine ligand for CD40

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Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand

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Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations?

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Inducible nitric oxide synthase activity of cloned murine microglial cells

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Assessment of intracellular TAP-1 and TAP-2 in conjunction with surface MHC class I in plasma cells from patients with multiple myeloma

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gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory

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The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion

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CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis

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Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis

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Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes

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Recombinant soluble trimeric CD40 ligand is biologically active

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Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin-12 for interferon-gamma production

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Leukocyte chemotactic factor, a natural ligand to CD4, is expressed by lymphocytes and microglial cells of the MS plaque

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Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion

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Interferon-gamma-inducing factor elicits antitumor immunity in association with interferon-gamma production

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Mice deficient for the CD40 ligand

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7 January 2021

10.1016/S0165-5728(99)00053-3

Identifiers

DOI

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9 February 2018

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9 February 2018