Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors (Q48178007)

9 February 2018

title

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors (English)

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Daniela Fiore

object named as

Daniela Fiore

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author name string

Dario R Lemos

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Farshad Babaeijandaghi

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Marcela Low

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Chih-Kai Chang

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Sunny T Lee

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Regan-Heng Zhang

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Anuradha Natarajan

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Sergei A Nedospasov

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language of work or name

English

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publication date

8 June 2015

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9 February 2018

published in

Nature Medicine

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9 February 2018

volume

21

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issue

7

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9 February 2018

page(s)

786-794

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9 February 2018

A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B.

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Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib.

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Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

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Identifiers

DOI

10.1038/NM.3869

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9 February 2018

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9 February 2018