Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain (Q48487111)

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scientific article published in January 2002

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English	Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain	scientific article published in January 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

0 references

immune challenge

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based on heuristic

inferred from title

3

object named as

Mark P Mattson

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

author name string

Jaewon Lee

1

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

Sic L Chan

2

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

publication date

1 January 2002

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

NeuroMolecular Medicine

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

2

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

1

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

29-45

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

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Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

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Neuroprotective and neurorescuing effects of isoform-specific nitric oxide synthase inhibitors, nitric oxide scavenger, and antioxidant against beta-amyloid toxicity

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

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Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer's disease brain.

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: in vitro and in vivo studies

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

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Glia: the not so innocent bystanders.

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

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Glial cytokines in Alzheimer's disease: Review and pathogenic implications

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

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Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

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Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early induction of interleukin-6 mRNA in the hippocampus and cortex of APPsw transgenic mice Tg2576.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread peroxynitrite-mediated damage in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of tumor necrosis factor-alpha mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of suppression subtractive hybridization for differential gene expression in stroke: discovery of CD44 gene expression and localization in permanent focal stroke in rats

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https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of macrophages by Alzheimer beta amyloid peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Life-long dietary restriction attenuates age-related increases in hippocampal glial fibrillary acidic protein mRNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Set back to Alzheimer vaccine studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain inflammation in Alzheimer disease and the therapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of interleukin-1 receptor antagonist isoform expression in the brain of lipopolysaccharide-treated rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: reversal by inhibition of the inducible NO synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiinflammatory effects of estrogen on microglial activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical-neuropathological correlations in Alzheimer's disease and related dementias

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of microglia with amyloid plaques in brains of APP23 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1beta, inducible nitric oxide synthase, and nuclear factor-kappaB are induced in morphologically distinct microglia after rat hippocampal lipopolysaccharide/interferon-gamma injection

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereological estimation of total microglia number in mouse hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial activation in Alzheimer's disease: the role of Abeta and its associated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of C5a and C3a complement fragment-induced [Ca2+]i signaling in mouse microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MHC class II-positive microglia in human brain: association with Alzheimer lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12230303

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1385/NMM:2:1:29

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12230303

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