Epistasis: too often neglected in complex trait studies? (Q48541812)

12 February 2018

review article

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title

Epistasis: too often neglected in complex trait studies? (English)

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12 February 2018

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1

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12 February 2018

Chris Haley

series ordinal

2

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12 February 2018

publication date

1 August 2004

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12 February 2018

published in

Nature Reviews Genetics

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12 February 2018

volume

5

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12 February 2018

issue

8

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12 February 2018

page(s)

618-625

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12 February 2018

Finding the molecular basis of quantitative traits: successes and pitfalls.

cites work

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MULTIFACTORIAL GENETICSUNDERSTANDING QUANTITATIVE GENETIC VARIATION

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A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle

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A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig.

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Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains.

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A global search reveals epistatic interaction between QTL for early growth in the chicken

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Little epistasis for anxiety-related measures in the DeFries strains of laboratory mice.

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Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

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Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1.

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Will haplotype maps be useful for finding genes?

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Genetic dissection of phenotypic diversity in farm animals

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Designing and analysing case-control studies to exploit independence of genotype and exposure

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Multipoint quantitative-trait linkage analysis in general pedigrees

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Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions

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Efficient algorithms for quantitative trait loci mapping problems

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The inheritance and expression of disorganization, an unusual mutation in the mouse

21 January 2018

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Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction

31 March 2020

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The investigation of linkage between a quantitative trait and a marker locus

31 March 2020

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Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse

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Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans.

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Use of randomization testing to detect multiple epistatic QTLs

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Genetic analysis of a new mouse model for non-insulin-dependent diabetes

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Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice

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Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci

31 March 2020

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A genome scan for Loci associated with aerobic running capacity in rats

31 March 2020

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Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice

31 March 2020

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Multipoint oligogenic linkage analysis of quantitative traits.

31 March 2020

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Effect of genetic architecture on the power of human linkage studies to resolve the contribution of quantitative trait loci

31 March 2020

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Power of variance component linkage analysis to detect epistasis

31 March 2020

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A simple regression method for mapping quantitative trait loci in line crosses using flanking markers

31 March 2020

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General score tests for associations of genetic markers with disease using cases and their parents.

31 March 2020

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A transmission disequilibrium test for quantitative trait loci

31 March 2020

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Linkage and association analyses of alcoholism using a regression-based transmission/disequilibrium test

31 March 2020

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A unified framework for transmission-disequilibrium test analysis of discrete and continuous traits

31 March 2020

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QTL analysis of self-selected macronutrient diet intake: fat, carbohydrate, and total kilocalories

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRG1407

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12 February 2018

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12 February 2018