Nonsense-mediated mRNA decay (NMD) mechanisms (Q40005465)

16 September 2017

title

Nonsense-mediated mRNA decay (NMD) mechanisms (English)

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16 September 2017

Saverio Brogna

1

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16 September 2017

Jikai Wen

series ordinal

2

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16 September 2017

publication date

1 February 2009

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Nature Structural & Molecular Biology

16 September 2017

published in

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16 September 2017

volume

16

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16 September 2017

issue

2

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16 September 2017

page(s)

107-113

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Polarity and the Degradation of mRNA

16 September 2017

cites work

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Early nonsense: mRNA decay solves a translational problem

21 January 2018

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Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

21 January 2018

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Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species

21 January 2018

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Mutations in the MOF2/SUI1 gene affect both translation and nonsense-mediated mRNA decay.

21 January 2018

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An internal open reading frame triggers nonsense-mediated decay of the yeast SPT10 mRNA.

21 January 2018

1 reference

SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast

21 January 2018

1 reference

SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans

21 January 2018

1 reference

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

21 January 2018

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Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

21 January 2018

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Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant

21 January 2018

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Widespread impact of nonsense-mediated mRNA decay on the yeast intronome

21 January 2018

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Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?

21 January 2018

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Nonsense-mediated mRNA decay: target genes and functional diversification of effectors

21 January 2018

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Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability

21 January 2018

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Functions of the nonsense-mediated mRNA decay pathway in Drosophila development

21 January 2018

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Arabidopsis UPF1 RNA helicase for nonsense-mediated mRNA decay is involved in seed size control and is essential for growth

21 January 2018

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NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

21 January 2018

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Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation

21 January 2018

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The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

21 January 2018

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Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay

21 January 2018

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Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

21 January 2018

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The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells

21 January 2018

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Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay

21 January 2018

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mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?

21 January 2018

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Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance

21 January 2018

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A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay

21 January 2018

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The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein

21 January 2018

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Poly(A)-binding protein acts in translation termination via eukaryotic release factor 3 interaction and does not influence [PSI(+)] propagation

21 January 2018

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At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation

21 January 2018

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Binary specification of nonsense codons by splicing and cytoplasmic translation

21 January 2018

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The human intronless melanocortin 4-receptor gene is NMD insensitive

21 January 2018

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Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay

21 January 2018

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A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

21 January 2018

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The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

21 January 2018

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NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

21 January 2018

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Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

21 January 2018

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The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling

21 January 2018

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The ever-increasing complexities of the exon junction complex

21 January 2018

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Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)

21 January 2018

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Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

21 January 2018

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Efficient downregulation of immunoglobulin mu mRNA with premature translation-termination codons requires the 5'-half of the VDJ exon

21 January 2018

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Boundary-independent polar nonsense-mediated decay

21 January 2018

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Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

21 January 2018

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Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway.

21 January 2018

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A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay

21 January 2018

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Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

21 January 2018

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EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length

21 January 2018

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A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay

21 January 2018

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Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region

21 January 2018

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Interference of nonsense mutations with eukaryotic messenger RNA stability

21 January 2018

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Nonsense mutations in the alcohol dehydrogenase gene of Drosophila melanogaster correlate with an abnormal 3' end processing of the corresponding pre-mRNA.

21 January 2018

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Initiation of translation can occur only in a restricted region of the CYC1 mRNA of Saccharomyces cerevisiae

21 January 2018

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Translation factors promote the formation of two states of the closed-loop mRNP.

21 January 2018

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A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation

21 January 2018

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Translation initiation factors eIF-iso4G and eIF-4B interact with the poly(A)-binding protein and increase its RNA binding activity

21 January 2018

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Nonsense-mediated decay does not occur within the yeast nucleus

21 January 2018

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Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping

21 January 2018

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Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells

21 January 2018

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Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay.

21 January 2018

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What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame?

21 January 2018

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eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA.

21 January 2018

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Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms

21 January 2018

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Cap-independent translation is required for starvation-induced differentiation in yeast

21 January 2018

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mRNA stabilization by poly(A) binding protein is independent of poly(A) and requires translation.

21 January 2018

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Nonsense-mediated mRNA decay in yeast does not require PAB1 or a poly(A) tail

21 January 2018

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A specific role for the C-terminal region of the Poly(A)-binding protein in mRNA decay

21 January 2018

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Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs

21 January 2018

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The histone 3'-terminal stem-loop-binding protein enhances translation through a functional and physical interaction with eukaryotic initiation factor 4G (eIF4G) and eIF3

21 January 2018

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Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1

21 January 2018

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Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay

21 January 2018

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Human INT6/eIF3e is required for nonsense-mediated mRNA decay

21 January 2018

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Recycling of eukaryotic posttermination ribosomal complexes

21 January 2018

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Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities

21 January 2018

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Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

21 January 2018

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SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

21 January 2018

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SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

21 January 2018

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Association of yeast Upf1p with direct substrates of the NMD pathway.

21 January 2018

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Step-wise formation of eukaryotic double-row polyribosomes and circular translation of polysomal mRNA.

21 January 2018

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A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation

21 January 2018

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Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA

21 January 2018

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A quantitative analysis of intron effects on mammalian gene expression

21 January 2018

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SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs

21 January 2018

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Ribosome components are associated with sites of transcription.

21 January 2018

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Coupled transcription and translation within nuclei of mammalian cells.

21 January 2018

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NASty effects on fibrillin pre-mRNA splicing: another case of ESE does it, but proposals for translation-dependent splice site choice live on.

21 January 2018

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Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements

21 January 2018

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An alternative branch of the nonsense-mediated decay pathway

21 January 2018

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Translational control of intron splicing in eukaryotes

21 January 2018

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mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor

21 January 2018

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The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay

31 March 2020

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Shape of large bound polysomes in cultured fibroblasts and thyroid epithelial cells

31 March 2020

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Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

31 March 2020

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smg-7 is required for mRNA surveillance in Caenorhabditis elegans.

31 March 2020

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12 December 2020

Nonsense mutations in the human beta-globin gene lead to unexpected levels of cytoplasmic mRNA accumulation

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12 December 2020

A splicing-dependent regulatory mechanism that detects translation signals

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12 December 2020

Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression

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12 December 2020

Frameshift suppression Saccharomyces cerevisiae. II. Genetic properties of group II suppressors.

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12 December 2020

When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

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12 December 2020

A new kind of informational suppression in the nematode Caenorhabditis elegans

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12 December 2020

Identifiers

DOI

10.1038/NSMB.1550

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Dimensions Publication ID

16 September 2017

1005363300

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Fatcat ID

release_idirkgc4yjeqbfuq3ldtjqwo74

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Fatcat

https://api.fatcat.wiki/v0/release/idirkgc4yjeqbfuq3ldtjqwo74

24 November 2022

mapped directly with Wikidata item

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