Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor, but leads to receptor down-regulation. (Q40084721)

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scientific article published on October 2007

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English	Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor, but leads to receptor down-regulation.	scientific article published on October 2007

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5 January 2020

Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor, but leads to receptor down-regulation (English)

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5 January 2020

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5 January 2020

Jarmo T Laitinen

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5 January 2020

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Maija Vaittinen

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1 October 2007

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5 January 2020

Journal of Pineal Research

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5 January 2020

43

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5 January 2020

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5 January 2020

255-262

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5 January 2020

Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

1 reference

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Melatonin receptors are for the birds: Molecular analysis of two receptor subtypes differentially expressed in chick brain

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Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores

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Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

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Melatonin receptors: localization, molecular pharmacology and physiological significance

1 reference

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Sensitization: a mechanism for melatonin action in the pars tuberalis

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G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

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Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor

1 reference

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Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure.

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The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor.

1 reference

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21 January 2018

[Gamma-35S]GTP autoradiography allows region-specific detection of muscarinic receptor-dependent G-protein activation in the chick optic tectum

1 reference

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21 January 2018

Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes

1 reference

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21 January 2018

Important amino acids for the function of the human MT1 melatonin receptor.

1 reference

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A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated

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Constitutive endocytic cycle of the CB1 cannabinoid receptor.

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Regulatory mechanisms that modulate signalling by G-protein-coupled receptors

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Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization

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Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications

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Chronic morphine-induced changes in mu-opioid receptors and G proteins of different subcellular loci in rat brain

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Hormone-induced subcellular redistribution of trimeric G proteins.

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Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors

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Short-term exposure to melatonin differentially affects the functional sensitivity and trafficking of the hMT1 and hMT2 melatonin receptors

1 reference

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21 January 2018

Melatonin-mediated regulation of human MT(1) melatonin receptors expressed in mammalian cells

1 reference

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21 January 2018

Melatonin decreases cell proliferation and transformation in a melatonin receptor-dependent manner

1 reference

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21 January 2018

Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal

1 reference

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21 January 2018

Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin

1 reference

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21 January 2018

Melatonin receptors and ligands

1 reference

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21 January 2018

Receptor downregulation and multivesicular-body sorting

1 reference

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21 January 2018

Modulation of postendocytic sorting of G protein-coupled receptors

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Differential sorting of human delta-opioid receptors after internalization by peptide and alkaloid agonists.

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Complexity of agonist- and cyclic AMP-mediated downregulation of the human beta 1-adrenergic receptor: role of internalization, degradation, and mRNA destabilization

1 reference

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Identifiers

10.1111/J.1600-079X.2007.00470.X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17803522%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17803522%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

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