Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. (Q40105282)

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2 January 2020

title

Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis (English)

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2 January 2020

2

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2 January 2020

author name string

Brooke Ancrile

series ordinal

1

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2 January 2020

Christopher M Counter

series ordinal

3

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2 January 2020

publication date

1 July 2007

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2 January 2020

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2 January 2020

volume

21

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2 January 2020

issue

14

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2 January 2020

page(s)

1714-1719

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Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.

2 January 2020

cites work

1 reference

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A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro

22 September 2017

1 reference

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Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice

22 September 2017

1 reference

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Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine

22 September 2017

1 reference

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Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance

22 September 2017

1 reference

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Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence.

22 September 2017

1 reference

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Targeting RAS signalling pathways in cancer therapy

22 September 2017

1 reference

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Activation of N-ras and K-ras induced by interleukin-6 in a myeloma cell line: implications for disease progression and therapeutic response

22 September 2017

1 reference

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Distinct requirements for Ras oncogenesis in human versus mouse cells

22 September 2017

1 reference

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Understanding Ras: 'it ain't over 'til it's over'.

22 September 2017

1 reference

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Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1920165

Interleukin 6 induces the expression of vascular endothelial growth factor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1920165

Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1920165

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1920165

Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer

22 September 2017

1 reference

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Anti-interleukin-6 monoclonal antibody induces regression of human prostate cancer xenografts in nude mice

25 September 2017

1 reference

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Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1.

25 September 2017

1 reference

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Discrete roles of cytokines, TNF-alpha, IL-1, IL-6 in tumor promotion and cell transformation

15 June 2018

1 reference

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Molecular and cellular biology of interleukin-6 and its receptor

15 June 2018

1 reference

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Impaired immune and acute-phase responses in interleukin-6-deficient mice.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1920165

Production of hybridoma growth factor by human monocytes.

15 June 2018

1 reference

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IL-1 stimulates IL-6 production in endothelial cells.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1920165

Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6.

15 June 2018

1 reference

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Interleukin-6 increases vascular endothelial growth factor and angiogenesis in gastric carcinoma

15 June 2018

1 reference

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Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1920165

Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase protein response in advanced pancreatic cancer

20 August 2018

1 reference

12 December 2020

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

1 reference

12 December 2020

Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis

1 reference

12 December 2020

Monoclonal antibody therapy of cancer

1 reference

12 December 2020

Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes

1 reference

12 December 2020

Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.1549407

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17639077%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

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2 January 2020

PubMed publication ID

17639077

1 reference