Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis (Q40191493)

18 September 2017

title

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis (English)

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18 September 2017

Irene Noguera-Troise

1

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18 September 2017

Christopher Daly

2

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18 September 2017

Nicholas J Papadopoulos

3

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18 September 2017

Sandra Coetzee

4

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18 September 2017

Pat Boland

5

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18 September 2017

Nicholas W Gale

6

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18 September 2017

Hsin Chieh Lin

7

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18 September 2017

George D Yancopoulos

8

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18 September 2017

Gavin Thurston

9

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18 September 2017

language of work or name

English

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publication date

1 December 2006

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18 September 2017

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18 September 2017

volume

444

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18 September 2017

issue

7122

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18 September 2017

page(s)

1032-1037

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Vascular endothelial growth factor as a target for anticancer therapy

18 September 2017

cites work

1 reference

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Possible mechanisms of acquired resistance to anti-angiogenic drugs: implications for the use of combination therapy approaches.

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Vascular-specific growth factors and blood vessel formation

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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

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7 January 2021

Angiogenesis in life, disease and medicine

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7 January 2021

Notch function in the vasculature: insights from zebrafish, mouse and man.

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7 January 2021

Notch signaling: cell fate control and signal integration in development

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7 January 2021

Notch signaling during vascular development

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7 January 2021

Dosage-sensitive requirement for mouse Dll4 in artery development

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Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

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7 January 2021

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

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7 January 2021

Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

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7 January 2021

Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function

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7 January 2021

A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling

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7 January 2021

Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression

1 reference

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7 January 2021

HES and HERP families: multiple effectors of the Notch signaling pathway

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7 January 2021

Notch signaling in primary endothelial cells

1 reference

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7 January 2021

The role of notch in modeling and maintaining the vasculature

1 reference

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7 January 2021

Nrarp is a novel intracellular component of the Notch signaling pathway

1 reference

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7 January 2021

The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway

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7 January 2021

Dissociation of angiogenesis and tumorigenesis in follistatin- and activin-expressing tumors

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7 January 2021

Tumor angiogenesis and accessibility: role of vascular endothelial growth factor

1 reference

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7 January 2021

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

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7 January 2021

Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1

1 reference

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7 January 2021

Identifiers

DOI

10.1038/NATURE05355

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Dimensions Publication ID

18 September 2017

1037678066

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