alpha-Synuclein fission yeast model: concentration-dependent aggregation without plasma membrane localization or toxicity (Q40327562)

19 September 2017

title

alpha-Synuclein fission yeast model: concentration-dependent aggregation without plasma membrane localization or toxicity (English)

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19 September 2017

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Katrina A Brandis

1

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19 September 2017

Isaac F Holmes

2

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19 September 2017

Samantha J England

3

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19 September 2017

Nijee Sharma

4

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19 September 2017

Lokesh Kukreja

5

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19 September 2017

Shubhik K DebBurman

6

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19 September 2017

publication date

1 January 2006

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Journal of Molecular Neuroscience

19 September 2017

published in

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19 September 2017

volume

28

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19 September 2017

issue

2

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19 September 2017

page(s)

179-191

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Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

19 September 2017

cites work

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12 December 2020

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

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12 December 2020

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

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Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations

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The rat brain synucleins; family of proteins transiently associated with neuronal membrane

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Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form

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12 December 2020

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

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12 December 2020

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Molecular genetics approaches in yeast to study amyloid diseases

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Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

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12 December 2020

Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease?

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12 December 2020

Protofibrils, the unifying toxic molecule of neurodegenerative disorders?

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12 December 2020

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

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12 December 2020

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

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12 December 2020

Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

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12 December 2020

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

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Neurodegenerative disease: amyloid pores from pathogenic mutations

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Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein

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12 December 2020

Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast

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12 December 2020

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

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12 December 2020

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

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12 December 2020

Yeast cells provide insight into alpha-synuclein biology and pathobiology

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De novo generation of a PrPSc-like conformation in living cells.

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The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

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DNA damage and cell cycle control in Schizosaccharomyces pombe

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12 December 2020

Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

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12 December 2020

Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

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12 December 2020

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

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Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?

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12 December 2020

Fluorescence studies suggest a role for alpha-synuclein in the phosphatidylinositol lipid signaling pathway

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12 December 2020

Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system

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12 December 2020

Prionics or the kinetic basis of prion diseases

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12 December 2020

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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12 December 2020

Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease

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Rapid Anionic Micelle-mediated α-Synuclein Fibrillization in Vitro

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

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Cell and tissue distribution and developmental change of neuron specific 14 kDa protein (phosphoneuroprotein 14)

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12 December 2020

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

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12 December 2020

Etiology and pathogenesis of Parkinson's disease

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12 December 2020

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

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12 December 2020

Molecular Pathways of Neurodegeneration in Parkinson's Disease

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12 December 2020

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

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12 December 2020

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

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12 December 2020

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

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12 December 2020

The genome sequence of Schizosaccharomyces pombe

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12 December 2020

Toxic proteins in neurodegenerative disease

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12 December 2020

Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions

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12 December 2020

Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

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12 December 2020

alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress

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12 December 2020

Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

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12 December 2020

Alpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast

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12 December 2020

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

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12 December 2020

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes

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12 December 2020

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

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12 December 2020

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

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12 December 2020

Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe

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12 December 2020

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

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12 December 2020

Metabolism of the phospholipid precursor inositol and its relationship to growth and viability in the natural auxotroph Schizosaccharomyces pombe

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12 December 2020

Parkinson's disease: mechanisms and models

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12 December 2020

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

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12 December 2020

Identifiers

DOI

10.1385/JMN:28:2:179

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Dimensions Publication ID

19 September 2017

1011265614

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