A mechanistic model of tau amyloid aggregation based on direct observation of oligomers (Q40343472)

19 September 2017

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers (English)

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19 September 2017

10

1 reference

19 September 2017

Sarah L Shammas

1

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Magnus Kjaergaard

object named as

Magnus Kjaergaard

4

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Eckhard Mandelkow

9

object named as

Eckhard Mandelkow

1 reference

19 September 2017

7

Eva Mandelkow

1 reference

19 September 2017

Gonzalo A Garcia

2

1 reference

19 September 2017

Satish Kumar

3

1 reference

19 September 2017

Mathew H Horrocks

5

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19 September 2017

Nadia Shivji

6

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19 September 2017

Tuomas P J Knowles

8

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19 September 2017

language of work or name

English

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publication date

30 April 2015

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19 September 2017

Nature Communications

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19 September 2017

6

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19 September 2017

7025

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Creative Commons Attribution 4.0 International

19 September 2017

start time

30 April 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission

22 September 2017

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Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

22 September 2017

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Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells

22 September 2017

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Direct observation of the interconversion of normal and toxic forms of α-synuclein

22 September 2017

1 reference

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Protein misfolded oligomers: experimental approaches, mechanism of formation, and structure-toxicity relationships

22 September 2017

1 reference

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Understanding the kinetic roles of the inducer heparin and of rod-like protofibrils during amyloid fibril formation by Tau protein

22 September 2017

1 reference

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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

22 September 2017

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Preparation and Characterization of Neurotoxic Tau Oligomers

22 September 2017

1 reference

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Prion-like mechanisms in neurodegenerative diseases

22 September 2017

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An analytical solution to the kinetics of breakable filament assembly

22 September 2017

1 reference

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Detection and quantification of tau aggregation using a membrane filter assay

22 September 2017

1 reference

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Determination of the fraction and stoichiometry of femtomolar levels of biomolecular complexes in an excess of monomer using single-molecule, two-color coincidence detection

22 September 2017

1 reference

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The MAP2/Tau family of microtubule-associated proteins

22 September 2017

1 reference

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Tau aggregation is driven by a transition from random coil to beta sheet structure

22 September 2017

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Surface-decoration of microtubules by human tau

22 September 2017

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Role of tau protein in both physiological and pathological conditions.

22 September 2017

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Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain

22 September 2017

1 reference

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Neurodegenerative tauopathies

22 September 2017

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Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

22 September 2017

1 reference

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High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands

22 September 2017

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RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

22 September 2017

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Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

22 September 2017

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Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity

25 September 2017

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Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

15 June 2018

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FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions

15 June 2018

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Conformational diversity of wild-type Tau fibrils specified by templated conformation change

15 June 2018

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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

15 June 2018

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Kinetics of sickle hemoglobin polymerization. II. A double nucleation mechanism.

15 June 2018

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β-Sheet core of tau paired helical filaments revealed by solid-state NMR.

15 June 2018

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The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments.

20 August 2018

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The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4421837

Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments

20 August 2018

1 reference

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

20 August 2018

1 reference

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Single Molecule Fluorescence under Conditions of Fast Flow

20 August 2018

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Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS8025

Fibrillogenic nuclei composed of P301L mutant tau induce elongation of P301L tau but not wild-type tau

21 January 2018

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12 December 2020

Domains of tau protein and interactions with microtubules

1 reference

12 December 2020

Variations in filament conformation dictate seeding barrier between three- and four-repeat tau

1 reference

12 December 2020

The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy

1 reference

12 December 2020

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

1 reference

12 December 2020

Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias

1 reference

12 December 2020

A theory of linear and helical aggregations of macromolecules

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS8025

1 reference

Dimensions Publication ID

19 September 2017

0 references

0 references

1 reference

19 September 2017

PubMed publication ID

25926130

1 reference