Regulation of the small GTPase Rheb by amino acids. (Q40371799)

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7 January 2020

title

Regulation of the small GTPase Rheb by amino acids (English)

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1

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7 January 2020

author name string

Bos JL

series ordinal

2

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7 January 2020

Zwartkruis FJ

series ordinal

3

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7 January 2020

language of work or name

English

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publication date

1 February 2006

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7 January 2020

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7 January 2020

volume

25

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issue

5

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page(s)

657-664

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Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

7 January 2020

cites work

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Mammalian TOR: a homeostatic ATP sensor

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7 January 2021

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

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TSC2 mediates cellular energy response to control cell growth and survival

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Regulation of TSC2 by 14-3-3 binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Tuberous sclerosis complex: from Drosophila to human disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

SKAR is a specific target of S6 kinase 1 in cell growth control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Integration of growth factor and nutrient signaling: implications for cancer biology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

TOR signalling and control of cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Stimulation of gene induction and cell growth by the Ras effector Rlf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209106

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16170341%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 January 2020

1034184478

0 references

1 reference