Model for growth hormone receptor activation based on subunit rotation within a receptor dimer (Q40382202)

20 September 2017

title

Model for growth hormone receptor activation based on subunit rotation within a receptor dimer (English)

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20 September 2017

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Erythropoietin receptor

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Growth hormone receptor

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identical protein binding

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Rebecca A Pelekanos

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William J McKinstry

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William J McKinstry

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Michael W Parker

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Michael W Parker

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author name string

Richard J Brown

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20 September 2017

Julian J Adams

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Yu Wan

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Kathryn Palethorpe

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Ruth M Seeber

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Thea A Monks

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Karin A Eidne

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Michael J Waters

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20 September 2017

publication date

21 August 2005

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Nature Structural & Molecular Biology

20 September 2017

published in

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volume

12

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issue

9

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page(s)

814-821

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Rational design of potent antagonists to the human growth hormone receptor

20 September 2017

cites work

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Activation of chimeric and full-length growth hormone receptors by growth hormone receptor monoclonal antibodies. A specific conformational change may be required for full-length receptor signaling.

31 March 2020

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A conformationally sensitive GHR [growth hormone (GH) receptor] antibody: impact on GH signaling and GHR proteolysis

31 March 2020

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Increased site 1 affinity improves biopotency of porcine growth hormone. Evidence against diffusion dependent receptor dimerization

31 March 2020

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Growth hormone (GH) and a GH antagonist promote GH receptor dimerization and internalization

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The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif

31 March 2020

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Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

31 March 2020

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Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer

31 March 2020

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Crystallization and preliminary X-ray diffraction analysis of the unliganded human growth hormone receptor

31 March 2020

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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

31 March 2020

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Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

31 March 2020

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A piston model for transmembrane signaling of the aspartate receptor

31 March 2020

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Crystal structure of rhodopsin: A G protein-coupled receptor

31 March 2020

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The PredictProtein server

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Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis

31 March 2020

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Applications of novel resonance energy transfer techniques to study dynamic hormone receptor interactions in living cells.

31 March 2020

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Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluorescence resonance energy transfer study

31 March 2020

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Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers

31 March 2020

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A homogenous assay to monitor the activity of the insulin receptor using Bioluminescence Resonance Energy Transfer

31 March 2020

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A heptad motif of leucine residues found in membrane proteins can drive self-assembly of artificial transmembrane segments

31 March 2020

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Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2

31 March 2020

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Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor

31 March 2020

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Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.

31 March 2020

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Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization

31 March 2020

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The role of receptor dimerization domain residues in growth hormone signaling

31 March 2020

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Dimerization and signal transduction of the growth hormone receptor

31 March 2020

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Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells

31 March 2020

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Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer

31 March 2020

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Differential sorting of two glucose transporters expressed in insulin-sensitive cells

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB977

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20 September 2017

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