FK506 and cyclosporin, molecular probes for studying intracellular signal transduction (Q40490248)

21 September 2017

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title

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction (English)

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21 September 2017

J. Liu

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7691065

22 August 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=7691065

22 August 2024

publication date

1 June 1993

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full work available at URL

21 September 2017

https://api.elsevier.com/content/article/PII:016756999390048P?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0167-5699(93)90048-P

https://api.elsevier.com/content/article/PII:016756999390048P?httpAccept=text/plain

22 August 2024

1 reference

https://api.crossref.org/works/10.1016/0167-5699(93)90048-P

22 August 2024

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21 September 2017

volume

14

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21 September 2017

issue

6

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21 September 2017

page(s)

290-295

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Biological effects of cyclosporin A: A new antilymphocytic agent

21 September 2017

cites work

1

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FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro

22 August 2024

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Cyclophilin: a specific cytosolic binding protein for cyclosporin A

22 August 2024

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https://api.crossref.org/works/10.1016/0167-5699(93)90048-P

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

22 August 2024

4

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https://api.crossref.org/works/10.1016/0167-5699(93)90048-P

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

22 August 2024

5

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https://api.crossref.org/works/10.1016/0167-5699(93)90048-P

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

22 August 2024

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https://api.crossref.org/works/10.1016/0167-5699(93)90048-P

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

22 August 2024

7

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

22 August 2024

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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

22 August 2024

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When worlds collide: immunosuppressants meet protein phosphatases

22 August 2024

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The mechanism of action of cyclosporin A and FK506

22 August 2024

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Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction

22 August 2024

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Cyclophilins: a new family of proteins involved in intracellular folding.

22 August 2024

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The mechanism of protein folding. Implications of in vitro refolding models for de novo protein folding and translocation in the cell

22 August 2024

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T cell antigen receptor activation pathways: The tyrosine kinase connection

22 August 2024

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Contingent genetic regulatory events in T lymphocyte activation

22 August 2024

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Molecular cloning and overexpression of the human FK506-binding protein FKBP

22 August 2024

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Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

22 August 2024

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Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

22 August 2024

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Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae.

22 August 2024

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Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA

22 August 2024

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Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

22 August 2024

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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

22 August 2024

34

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FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

22 August 2024

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Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

22 August 2024

36

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The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer

22 August 2024

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The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter

22 August 2024

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Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40.

22 August 2024

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Identification of a putative regulator of early T cell activation genes

22 August 2024

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Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

22 August 2024

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Nuclear factor of activated T cells contains Fos and Jun.

22 August 2024

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The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5.

22 August 2024

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A seventeen kilodaltons peptidyl-prolyl cis-trans isomerase of the cyclosporin-producer Tolypocladium inflatum is sensitive to cyclosporin A

22 August 2024

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FK-506-binding proteins from streptomycetes producing immunosuppressive macrolactones of the FK-506 type

22 August 2024

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Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex

22 August 2024

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High brain densities of the immunophilin FKBP colocalized with calcineurin

22 August 2024

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Solution structure of the cyclosporin A/cyclophilin complex by NMR

22 August 2024

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X-ray structure of a decameric cyclophilin-cyclosporin crystal complex

22 August 2024

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Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

22 August 2024

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The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin

22 August 2024

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Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition

22 August 2024

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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

22 August 2024

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22 August 2024

Identifiers

1 reference

21 September 2017

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