Mouse genetics in the 21st century: using gene targeting to create a cornucopia of mouse mutants possessing precise genetic modifications (Q40533324)

21 September 2017

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title

Mouse genetics in the 21st century: using gene targeting to create a cornucopia of mouse mutants possessing precise genetic modifications (English)

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21 September 2017

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P J Wilder

1

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21 September 2017

A Rizzino

series ordinal

2

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21 September 2017

publication date

1 January 1993

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21 September 2017

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21 September 2017

volume

11

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21 September 2017

issue

2

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21 September 2017

page(s)

79-99

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High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination

21 September 2017

cites work

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https://api.crossref.org/works/10.1007%2FBF00748997

Reexamination of Gene Targeting Frequency as a Function of the Extent of Homology between the Targeting Vector and the Target Locus

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00748997

Low level of Hox1.3 gene expression does not preclude the use of promoterless vectors to generate a targeted gene disruption. off

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00748997

Production of homozygous mutant ES cells with a single targeting construct

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00748997

Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00748997

High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00748997

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00748997

Double-strand gap repair in a mammalian gene targeting reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00748997

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

21 January 2018

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12 December 2020

Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles

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12 December 2020

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12 December 2020

Targeting of nonexpressed genes in embryonic stem cells via homologous recombination

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12 December 2020

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

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12 December 2020

Profound block in thymocyte development in mice lacking p56lck

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12 December 2020

Inherited resistance to N- and B-tropic murine leukemia viruses in vitro: evidence that congenic mouse strains SIM and SIM.R differ at the Fv-1 locus

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12 December 2020

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

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12 December 2020

Targeted integration of the Ren-1D locus in mouse embryonic stem cells

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12 December 2020

Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene

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12 December 2020

Evidence for intrachromosomal gene conversion in cultured mouse cells.

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12 December 2020

Problems encountered in detecting a targeted gene by the polymerase chain reaction

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12 December 2020

Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death

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12 December 2020

Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro

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12 December 2020

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

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12 December 2020

Using embryonic stem cells to introduce mutations into the mouse germ line

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12 December 2020

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.

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12 December 2020

Polarized and functional epithelia can form after the targeted inactivation of both mouse keratin 8 alleles

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12 December 2020

Formation of germ-line chimeras from embryonic stem cells maintained with recombinant leukemia inhibitory factor

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12 December 2020

Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells

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12 December 2020

Scoring a technical knockout in mice

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12 December 2020

CD8 is needed for development of cytotoxic T cells but not helper T cells

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12 December 2020

Modulation of gene activity by consecutive gene targeting of one creatine kinase M allele in mouse embryonic stem cells

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12 December 2020

Targeting of the creatine kinase M gene in embryonic stem cells using isogenic and nonisogenic vectors

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12 December 2020

Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity

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12 December 2020

Establishment of a germ-line competent C57BL/6 embryonic stem cell line

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12 December 2020

Development of cytochalasin in B-induced tetraploid and diploid/tetraploid mosaic mouse embryos

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12 December 2020

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

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12 December 2020

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

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12 December 2020

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells

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12 December 2020

Embryonic stem cells alone are able to support fetal development in the mouse.

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12 December 2020

Establishment in culture of pluripotential cells from mouse embryos

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12 December 2020

Subtle Cerebellar Phenotype in Mice Homozygous for a Targeted Deletion of the En-2 Homeobox

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12 December 2020

A critical role of λ5 protein in B cell development

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12 December 2020

A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency

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12 December 2020

Cystic fibrosis in the mouse by targeted insertional mutagenesis

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12 December 2020

Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis

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12 December 2020

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

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12 December 2020

Generation and analysis of interleukin-4 deficient mice

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12 December 2020

Parental imprinting of the mouse insulin-like growth factor II gene.

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12 December 2020

Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection

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12 December 2020

Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination

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12 December 2020

Cell autonomous expression of IgD is not essential for the maturation of conventional B cells

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12 December 2020

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

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12 December 2020

Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.

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12 December 2020

Mice develop normally without tenascin

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12 December 2020

A pgk::hprt fusion as a selectable marker for targeting of genes in mouse embryonic stem cells: disruption of the T-cell receptor δ-chain-encoding gene

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12 December 2020

Gene targeting in embryonic stem cells

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12 December 2020

Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.

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12 December 2020

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

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12 December 2020

Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein

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12 December 2020

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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12 December 2020

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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12 December 2020

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

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12 December 2020

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

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12 December 2020

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

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12 December 2020

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

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12 December 2020

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

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12 December 2020

Recombinant fragment assay for gene targetting based on the polymerase chain reaction

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12 December 2020

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination

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12 December 2020

Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice

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12 December 2020

Mice lacking MHC class II molecules

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12 December 2020

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

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12 December 2020

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells.

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12 December 2020

Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I

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12 December 2020

Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons.

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12 December 2020

Homologous integration in mammalian cells without target gene selection

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12 December 2020

Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region

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12 December 2020

Targeted correction of a major histocompatibility class II E alpha gene by DNA microinjected into mouse eggs

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12 December 2020

Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene

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12 December 2020

Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells

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12 December 2020

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

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12 December 2020

A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung

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12 December 2020

Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes.

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12 December 2020

Targeted replacement of the homeobox gene Hox-3.1 by the Escherichia coli lacZ in mouse chimeric embryos

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12 December 2020

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

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12 December 2020

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs

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12 December 2020

Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting

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12 December 2020

An animal model for cystic fibrosis made by gene targeting

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12 December 2020

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

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12 December 2020

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

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12 December 2020

Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells

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12 December 2020

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

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12 December 2020

Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells

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12 December 2020

The new mouse genetics: altering the genome by gene targeting

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12 December 2020

Requirement for a functional Rb-1 gene in murine development

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12 December 2020

A dominant positive and negative selectable gene for use in mammalian cells

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12 December 2020

High frequency targeting of genes to specific sites in the mammalian genome

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12 December 2020

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

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12 December 2020

Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells

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12 December 2020

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination.

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12 December 2020

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

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12 December 2020

Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.

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12 December 2020

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

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12 December 2020

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

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12 December 2020

Effects of an Rb mutation in the mouse

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12 December 2020

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

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12 December 2020

RAG-1-deficient mice have no mature B and T lymphocytes

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12 December 2020

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

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12 December 2020

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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12 December 2020

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12 December 2020

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

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12 December 2020

Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells

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12 December 2020

Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice

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12 December 2020

Isolation of embryonic stem (ES) cells in media supplemented with recombinant leukemia inhibitory factor (LIF).

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12 December 2020

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

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12 December 2020

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

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12 December 2020

Embryonic stem cells and homologous recombination

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12 December 2020

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells

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12 December 2020

Identifiers

DOI

10.1007/BF00748997

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Dimensions Publication ID

21 September 2017

1001006184

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