Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity. (Q40586657)

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8 December 2019

title

Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity (English)

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8 December 2019

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ChEBI release 2020-05-28

Giuseppe Battaglia

1

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8 December 2019

Francesco Fornai

2

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8 December 2019

Carla L Busceti

3

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8 December 2019

Gabriella Aloisi

4

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8 December 2019

Franca Cerrito

5

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8 December 2019

Antonio De Blasi

6

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8 December 2019

Daniela Melchiorri

7

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8 December 2019

Ferdinando Nicoletti

8

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language of work or name

English

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publication date

1 March 2002

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8 December 2019

published in

Journal of Neuroscience

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8 December 2019

volume

22

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issue

6

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8 December 2019

page(s)

2135-2141

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Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress.

8 December 2019

cites work

1 reference

12 December 2020

Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones

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12 December 2020

Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse

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12 December 2020

Striatal subregions are differentially vulnerable to the neurotoxic effects of methamphetamine

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Modulation of the neurotoxic effects of methamphetamine by the selective kappa-opioid receptor agonist U69593.

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12 December 2020

Effects of repeated administration of a high dose of methamphetamine on dopamine and glutamate release in rat striatum and nucleus accumbens

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12 December 2020

The ontogeny of aggregation-enhanced toxicity

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12 December 2020

Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes

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12 December 2020

Endogenous activation of group-I metabotropic glutamate receptors is required for differentiation and survival of cerebellar Purkinje cells.

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12 December 2020

Methamphetamine-induced neuronal damage: a possible role for free radicals

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12 December 2020

Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5.

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12 December 2020

Methamphetamine and the expanding complications of amphetamines

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12 December 2020

Striatal dopamine nerve terminal markers in human, chronic methamphetamine users

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12 December 2020

Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine

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12 December 2020

Calcium and excitotoxic neuronal injury.

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12 December 2020

Role of glutamate in neurodegeneration of dopamine neurons in several animal models of parkinsonism

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12 December 2020

Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.

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12 December 2020

Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity.

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12 December 2020

The effects of methamphetamine on the production of free radicals and oxidative stress

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12 December 2020

Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons

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12 December 2020

Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine.

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12 December 2020

Methamphetamine-induced neurotoxicity: roles for glutamate and dopamine efflux

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12 December 2020

Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents

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12 December 2020

Contributions of mGlu1 and mGlu5 receptors to interactions with N-methyl-D-aspartate receptor-mediated responses and nociceptive sensory responses of rat thalamic neurons

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12 December 2020

Multiple methamphetamine injections induce marked increases in extracellular striatal dopamine which correlate with subsequent neurotoxicity

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12 December 2020

Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems

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12 December 2020

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

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12 December 2020

Developmental dissociation of methamphetamine-induced depletion of dopaminergic terminals and astrocyte reaction in rat striatum

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12 December 2020

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective

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12 December 2020

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12 December 2020

Changes in the gene expression of GABA(A) receptor alpha1 and alpha2 subunits and metabotropic glutamate receptor 5 in the basal ganglia of the rats with unilateral 6-hydroxydopamine lesion and embryonic mesencephalic grafts

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12 December 2020

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

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12 December 2020

Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice

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12 December 2020

Effects of pretreatment with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on methamphetamine pharmacokinetics and striatal dopamine losses

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12 December 2020

Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors

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12 December 2020

A method for concurrent measurement of picomole quantities of acetylcholine, choline, dopamine, norepinephrine, serotonin, 5-hydroxytryptophan, 5-hydroxyindoleacetic acid, tryptophan, tyrosine, glycine, aspartate, glutamate, alanine, and gamma-amino

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12 December 2020

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation

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12 December 2020

Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

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12 December 2020

Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893).

1 reference

12 December 2020

Methamphetamine neurotoxicity and striatal glutamate release: comparison to 3,4-methylenedioxymethamphetamine

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12 December 2020

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12 December 2020

Protein measurement with the Folin phenol reagent

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12 December 2020

Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity

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12 December 2020

Further studies of the role of hyperthermia in methamphetamine neurotoxicity.

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12 December 2020

10.1523/JNEUROSCI.22-06-02135.2002

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11896153%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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8 December 2019

PubMed publication ID

11896153

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