Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation (Q40635020)

22 September 2017

title

Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation (English)

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22 September 2017

Shelton JG

1

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22 September 2017

Moye PW

2

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22 September 2017

Steelman LS

3

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22 September 2017

Blalock WL

4

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22 September 2017

Lee JT

5

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22 September 2017

Franklin RA

6

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22 September 2017

McMahon M

7

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22 September 2017

McCubrey JA

8

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22 September 2017

publication date

1 September 2003

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22 September 2017

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22 September 2017

volume

17

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22 September 2017

issue

9

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22 September 2017

page(s)

1765-1782

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The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

22 September 2017

cites work

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The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors

21 January 2018

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Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

21 January 2018

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Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies

21 January 2018

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Mechanisms of resistance to imatinib (STI571) and prospects for combination with conventional chemotherapeutic agents

21 January 2018

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Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

21 January 2018

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Serine/threonine phosphorylation in cytokine signal transduction

21 January 2018

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Paradoxical activation of Raf by a novel Raf inhibitor

21 January 2018

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The development and therapeutic potential of protein kinase inhibitors

21 January 2018

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

21 January 2018

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Discovery of a novel Raf kinase inhibitor

21 January 2018

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

21 January 2018

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MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products

21 January 2018

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The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

21 January 2018

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Growth of factor-dependent hemopoietic precursor cell lines

21 January 2018

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Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.

21 January 2018

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Suppression of apoptosis: role in cell growth and neoplasia

21 January 2018

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Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line

21 January 2018

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Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

21 January 2018

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A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

21 January 2018

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Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.

21 January 2018

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Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells

21 January 2018

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Differential effects of retroviral long terminal repeats on interleukin-3 gene expression and autocrine transformation.

21 January 2018

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Characterization of proteins binding the 3' regulatory region of the IL-3 gene in IL-3-dependent and autocrine-transformed hematopoietic cells.

21 January 2018

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Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

21 January 2018

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Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.

21 January 2018

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Kinases: positive and negative regulators of apoptosis.

21 January 2018

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Jaks and Stats in cytokine signaling

21 January 2018

1 reference

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P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.

21 January 2018

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Oncogene-dependent engraftment of human myeloid leukemia cells in immunosuppressed mice

21 January 2018

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Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

21 January 2018

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Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1.

21 January 2018

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Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

21 January 2018

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Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

21 January 2018

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappaB-mediated antiapoptosis involving c-IAP2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

Ras- and Raf-induced down-modulation of non-muscle tropomyosin are MEK-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

A Raf-induced, MEK-independent signaling pathway regulates atrial natriuretic factor gene expression in cardiac muscle cells

21 January 2018

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Mutations of the BRAF gene in human cancer

21 January 2018

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Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

21 January 2018

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Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

21 January 2018

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Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells

21 January 2018

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B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

BAY 43-9006: early clinical data in patients with advanced solid malignancies

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

Design and discovery of small molecules targeting raf-1 kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

21 January 2018

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Antisense anticancer oligonucleotide therapeutics

21 January 2018

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Anti-(Raf-1) RNA aptamers that inhibit Ras-induced Raf-1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

7 January 2021

Diphtheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

7 January 2021

Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

7 January 2021

Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403052

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403052

1 reference

Dimensions Publication ID

22 September 2017

1010826794

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