Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. (Q40658272)

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2 November 2019

title

Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73 (English)

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2 November 2019

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Maria Lokshin

2

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2 November 2019

Isabelle Gross

3

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2 November 2019

Danielle Levasseur

4

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2 November 2019

Yoichi Taya

5

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2 November 2019

Jean-Philippe Loeffler

6

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2 November 2019

language of work or name

English

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publication date

3 April 2003

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Journal of Biological Chemistry

2 November 2019

published in

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2 November 2019

volume

278

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2 November 2019

issue

30

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2 November 2019

page(s)

27421-27431

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p73 is a simian [correction of human] p53-related protein that can induce apoptosis

2 November 2019

cites work

1 reference

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Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

21 January 2018

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Cloning and functional analysis of human p51, which structurally and functionally resembles p53

21 January 2018

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A novel protein with strong homology to the tumor suppressor p53.

21 January 2018

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21 January 2018

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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

21 January 2018

1 reference

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Two new p73 splice variants, gamma and delta, with different transcriptional activity.

21 January 2018

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

21 January 2018

1 reference

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A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

21 January 2018

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Induction of neuronal differentiation by p73 in a neuroblastoma cell line

21 January 2018

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An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

21 January 2018

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Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

21 January 2018

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

21 January 2018

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

21 January 2018

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Regulation of p73 by c-Abl through the p38 MAP kinase pathway.

21 January 2018

1 reference

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MDM2 suppresses p73 function without promoting p73 degradation

21 January 2018

1 reference

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MDM2 and MDMX bind and stabilize the p53-related protein p73

21 January 2018

1 reference

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Mdm2 binds p73 alpha without targeting degradation

21 January 2018

1 reference

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Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

21 January 2018

1 reference

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 January 2018

1 reference

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A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

1 reference

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Physical interaction with Yes-associated protein enhances p73 transcriptional activity

21 January 2018

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Differential effect of ik3-1/cables on p53- and p73-induced cell death

21 January 2018

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Role for the p53 homologue p73 in E2F-1-induced apoptosis

21 January 2018

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Role of the p53-homologue p73 in E2F1-induced apoptosis

21 January 2018

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Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

21 January 2018

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A rapid, quantitative and inexpensive method for detecting apoptosis by flow cytometry in transiently transfected cells

21 January 2018

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Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.

21 January 2018

1 reference

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Structural principles in cell-cycle control: beyond the CDKs

21 January 2018

1 reference

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The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

21 January 2018

1 reference

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A p34(cdc2) survival checkpoint in cancer

21 January 2018

1 reference

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Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

21 January 2018

1 reference

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

21 January 2018

1 reference

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Different p73 splicing variants are expressed in distinct tumour areas of a multifocal neuroblastoma

21 January 2018

1 reference

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p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

21 January 2018

1 reference

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Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M300251200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12676926%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference