Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation (Q40716855)

23 September 2017

title

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation (English)

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23 September 2017

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6

Dennis J Selkoe

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23 September 2017

W Taylor Kimberly

1

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23 September 2017

Matthew J LaVoie

2

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23 September 2017

Beth L Ostaszewski

3

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23 September 2017

Wenjuan Ye

4

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23 September 2017

Michael S Wolfe

5

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23 September 2017

language of work or name

English

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publication date

18 July 2002

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Journal of Biological Chemistry

23 September 2017

published in

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23 September 2017

volume

277

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23 September 2017

issue

38

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23 September 2017

page(s)

35113-35117

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A portrait of Alzheimer secretases--new features and familiar faces

23 September 2017

cites work

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

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Where Notch and Wnt signaling meet. The presenilin hub

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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Presenilin is required for activity and nuclear access of Notch in Drosophila

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A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

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Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

21 January 2018

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Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

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Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

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Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

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Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

21 January 2018

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Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

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Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

21 January 2018

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M204446200

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23 September 2017

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