The long and short isoforms of Ret function as independent signaling complexes. (Q40721459)

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10 November 2019

title

The long and short isoforms of Ret function as independent signaling complexes (English)

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10 November 2019

4

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10 November 2019

author name string

Brian A Tsui-Pierchala

1

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10 November 2019

Rebecca C Ahrens

2

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10 November 2019

Robert J Crowder

3

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10 November 2019

Eugene M Johnson

5

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10 November 2019

language of work or name

English

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publication date

28 June 2002

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Journal of Biological Chemistry

10 November 2019

number of pages

8

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based on heuristic

inferred from page(s)

published in

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10 November 2019

volume

277

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10 November 2019

issue

37

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10 November 2019

page(s)

34618-34625

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The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease

10 November 2019

cites work

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GDNF family neurotrophic factor signaling: four masters, one servant?

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The GDNF/RET signaling pathway and human diseases

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The RET receptor: function in development and dysfunction in congenital malformation

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Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities

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Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain

21 January 2018

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The Ret Receptor Protein Tyrosine Kinase Associates with the SH2-containing Adapter Protein Grb10

21 January 2018

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The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma

21 January 2018

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Grb2 binding to the different isoforms of Ret tyrosine kinase.

21 January 2018

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A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins

21 January 2018

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Identification of Shc docking site on Ret tyrosine kinase

21 January 2018

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Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation

21 January 2018

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Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

21 January 2018

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Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

21 January 2018

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Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

21 January 2018

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The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.

21 January 2018

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Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis

21 January 2018

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NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons.

21 January 2018

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Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.

21 January 2018

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Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

21 January 2018

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GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival

21 January 2018

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Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins

21 January 2018

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Preserved phosphorylation of RET receptor protein in spinal motor neurons of patients with amyotrophic lateral sclerosis: an immunohistochemical study by a phosphorylation-specific antibody at tyrosine 1062.

21 January 2018

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Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival

21 January 2018

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Calcium-dependent Ret activation by GDNF and neurturin

21 January 2018

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Fibroblast Growth Factor Receptors from Liver Vary in Three Structural Domains

21 January 2018

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Cloning of a fibroblast growth factor receptor 1 splice variant from Xenopus embryos that lacks a protein kinase C site important for the regulation of receptor activity

21 January 2018

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Naturally Occurring Tyrosine Kinase Inserts Block High Affinity Binding of Phospholipase Cγ and Shc to TrkC and Neurotrophin-3 Signaling

21 January 2018

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The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells

21 January 2018

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Alternative forms of rat TrkC with different functional capabilities

21 January 2018

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A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals

21 January 2018

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RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2

21 January 2018

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TrkC isoforms with inserts in the kinase domain show impaired signaling responses

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M203580200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12091387%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1 reference