S6K Promotes Dopaminergic Neuronal Differentiation Through PI3K/Akt/mTOR-Dependent Signaling Pathways in Human Neural Stem Cells (Q40768338)

23 September 2017

title

S6K Promotes Dopaminergic Neuronal Differentiation Through PI3K/Akt/mTOR-Dependent Signaling Pathways in Human Neural Stem Cells (English)

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23 September 2017

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Jeong Eun Lee

1

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23 September 2017

Mi Sun Lim

2

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23 September 2017

Jae Hyun Park

3

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23 September 2017

Chang Hwan Park

4

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23 September 2017

Hyun Chul Koh

5

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23 September 2017

publication date

5 July 2015

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23 September 2017

published in

Molecular Neurobiology

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23 September 2017

volume

53

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23 September 2017

issue

6

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23 September 2017

page(s)

3771-3782

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Adult neurogenesis and neural stem cells of the central nervous system in mammals

23 September 2017

cites work

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Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis

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Modulation of the PI 3-kinase-Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem/precursor cells

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Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin

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The target of rapamycin (TOR) proteins

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mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells

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Initiation of neuronal differentiation requires PI3-kinase/TOR signalling in the vertebrate neural tube

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mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells

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Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease

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Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.

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Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation

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Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.

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G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to specify embryonic stem cells toward the cardiac lineage through extracellular signal-regulated kinase/p70S6 kinase signaling pathway

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Novel 5'TOPmRNAs regulated by ribosomal S6 kinase are important for cardiomyocyte development: S6 kinase suppression limits cardiac differentiation and promotes pluripotent cells toward a neural lineage.

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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

21 January 2018

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Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus.

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12 December 2020

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

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12 December 2020

Control of translation by the target of rapamycin proteins.

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12 December 2020

Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro

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12 December 2020

Estimation of nuclear population from microtome sections

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12 December 2020

10.1007/S12035-015-9325-9

Identifiers

DOI

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Dimensions Publication ID

23 September 2017

1022128965

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