Differential activation of the Rac pathway by Ha-Ras and K-Ras (Q40816808)

24 September 2017

title

Differential activation of the Rac pathway by Ha-Ras and K-Ras (English)

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24 September 2017

Walsh AB

1

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24 September 2017

Bar-Sagi D

series ordinal

2

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24 September 2017

language of work or name

English

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publication date

14 February 2001

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Journal of Biological Chemistry

24 September 2017

published in

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24 September 2017

volume

276

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24 September 2017

issue

19

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24 September 2017

page(s)

15609-15615

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https://api.crossref.org/works/10.1074%2FJBC.M010573200

24 September 2017

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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

The murine N-ras gene is not essential for growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Increasing complexity of Ras signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Ras effectors and their role in mitogenesis and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

An essential role for Rac in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Rho GTPases and signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

A Rac1 effector site controlling mitogenesis through superoxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Suppression of Ras-induced apoptosis by the Rac GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Rho GTPases control polarity, protrusion, and adhesion during cell movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Functional rafts in cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Electrostatic interaction of myristoylated proteins with membranes: simple physics, complicated biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Pleckstrin homology domains: a common fold with diverse functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Signalling enzymes: bursting with potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Rho GTPases and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Oncogenic c-Ki-ras but not oncogenic c-Ha-ras up-regulates CEA expression and disrupts basolateral polarity in colon epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

K-ras point mutations in human colorectal carcinomas: relation to aneuploidy and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Mutation of Ha-Ras C Terminus Changes Effector Pathway Utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

Determination of tumor aggressiveness in colorectal cancer by K-ras-2 analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010573200

21 January 2018

Identifiers

DOI

10.1074/JBC.M010573200

1 reference

24 September 2017

1 reference