Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor (Q40820073)

24 September 2017

title

Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor (English)

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24 September 2017

Haskell-Luevano C

1

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24 September 2017

Monck EK

series ordinal

2

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24 September 2017

publication date

1 May 2001

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24 September 2017

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24 September 2017

volume

99

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24 September 2017

issue

1

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24 September 2017

page(s)

1-7

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Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

24 September 2017

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Molecular cloning, expression, and characterization of a fifth melanocortin receptor

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Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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Characterization of Agouti-related protein binding to melanocortin receptors

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Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

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Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

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Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice

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7 January 2021

Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat

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7 January 2021

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

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7 January 2021

Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues

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Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

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Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics

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7 January 2021

Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade

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7 January 2021

A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor.

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Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin recep

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7 January 2021

Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions

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7 January 2021

Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats

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7 January 2021

Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior

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7 January 2021

A receptor subtype involved in neuropeptide-Y-induced food intake

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7 January 2021

Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain.

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7 January 2021

Switching agonist/antagonist properties of opiate alkaloids at the delta opioid receptor using mutations based on the structure of the orphanin FQ receptor

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7 January 2021

AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor

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7 January 2021

10.1016/S0167-0115(01)00234-8

Identifiers

DOI

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24 September 2017

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