Insights into the mechanism of inhibition of novel bacterial topoisomerase inhibitors from characterization of resistant mutants of Staphylococcus aureus (Q40833065)

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English	Insights into the mechanism of inhibition of novel bacterial topoisomerase inhibitors from characterization of resistant mutants of Staphylococcus aureus	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Insights into the mechanism of inhibition of novel bacterial topoisomerase inhibitors from characterization of resistant mutants of Staphylococcus aureus (English)

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Staphylococcus aureus

1 reference

based on heuristic

inferred from title

author name string

Sushmita D Lahiri

1

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Amy Kutschke

2

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Kathy McCormack

3

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Richard A Alm

4

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

language of work or name

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publication date

15 June 2015

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Europe PubMed Central

PMC publication ID

24 September 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

PMC publication ID

24 September 2017

59

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

9

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

5278-5287

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae.

1 reference

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24 September 2017

Oxabicyclooctane-Linked Novel Bacterial Topoisomerase Inhibitors as Broad Spectrum Antibacterial Agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538526

24 September 2017

Multidrug-resistant and extensively drug-resistant Gram-negative pathogens: current and emerging therapeutic approaches.

1 reference

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24 September 2017

NBTI 5463 is a novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538526

24 September 2017

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding

1 reference

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24 September 2017

Which antibiotic for resistant Gram-positives, and why?

1 reference

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24 September 2017

Treatment of infections due to resistant Staphylococcus aureus

1 reference

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New antibiotics for bad bugs: where are we?

1 reference

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24 September 2017

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

1 reference

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24 September 2017

Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport

1 reference

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24 September 2017

Mapping the spectrum of conformational states of the DNA- and C-gates in Bacillus subtilis gyrase

1 reference

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24 September 2017

The role of DNA bending in type IIA topoisomerase function

1 reference

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24 September 2017

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

1 reference

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Global fluoroquinolone resistance epidemiology and implictions for clinical use.

1 reference

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24 September 2017

The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage

1 reference

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24 September 2017

Improving known classes of antibiotics: an optimistic approach for the future

1 reference

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24 September 2017

All tangled up: how cells direct, manage and exploit topoisomerase function

1 reference

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Current and novel antibiotics against resistant Gram-positive bacteria

1 reference

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Challenges of antibacterial discovery

1 reference

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24 September 2017

Type IIA topoisomerase inhibition by a new class of antibacterial agents

1 reference

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24 September 2017

Structural basis of gate-DNA breakage and resealing by type II topoisomerases

1 reference

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24 September 2017

Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

1 reference

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24 September 2017

Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors

1 reference

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24 September 2017

Structural basis for gate-DNA recognition and bending by type IIA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538526

24 September 2017

In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant gram-positive and fastidious organism groups

1 reference

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24 September 2017

Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538526

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Sequential acquisition of norfloxacin and ofloxacin resistance by methicillin-resistant and -susceptible Staphylococcus aureus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538526

24 September 2017

Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538526

24 September 2017

Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4538526

17 June 2018

Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases

1 reference

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Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases

1 reference

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Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.

1 reference

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Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity

1 reference

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19 August 2018

Functional determinants of gate-DNA selection and cleavage by bacterial type II topoisomerases

1 reference

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Multi-drug resistant bacteria and antibiotics

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Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile

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First case of VRSA identified in Michigan.

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Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity

1 reference

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Evaluation of quinolone resistance-determining region mutations and efflux pump expression in Neisseria meningitidis resistant to fluoroquinolones

1 reference

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Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections

1 reference

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Identifiers

10.1128/AAC.00571-15

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Europe PubMed Central

PMC publication ID

24 September 2017

release_2jhkj3rxljdareg34p4hvqkcsi

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24 November 2022

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

PubMed publication ID

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Europe PubMed Central

PMC publication ID

24 September 2017

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