Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance (Q40897154)

24 September 2017

title

Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance (English)

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24 September 2017

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1

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24 September 2017

Han TY

2

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24 September 2017

Giuliano AE

series ordinal

3

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24 September 2017

Hansen N

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4

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24 September 2017

Cabot MC

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5

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24 September 2017

language of work or name

English

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publication date

1 March 2000

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Journal of Biological Chemistry

24 September 2017

published in

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24 September 2017

volume

275

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24 September 2017

issue

10

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24 September 2017

page(s)

7138-7143

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Regulation of ceramide production and apoptosis

24 September 2017

cites work

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Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

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Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to tumor necrosis factor-alpha-mediated cytotoxicity

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Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

21 January 2018

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Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells

21 January 2018

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Accumulation of glucosylceramides in multidrug-resistant cancer cells

21 January 2018

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Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells

21 January 2018

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Glycosylation of ceramide potentiates cellular resistance to tumor necrosis factor-alpha-induced apoptosis

21 January 2018

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21 January 2018

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Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis

21 January 2018

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Glucosyceramide synthase of mouse kidney: further characterization with an improved assay method.

21 January 2018

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Up-regulation of glucosylceramide synthase expression and activity during human keratinocyte differentiation

21 January 2018

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Biochemical and pharmacological characterization of MCF-7 drug-sensitive and AdrR multidrug-resistant human breast tumor xenografts in athymic nude mice

21 January 2018

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A human cell line from a pleural effusion derived from a breast carcinoma

21 January 2018

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Biological roles of oligosaccharides: all of the theories are correct

21 January 2018

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A vital role for glycosphingolipid synthesis during development and differentiation

21 January 2018

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Mass spectrometric identification of increased C16 ceramide levels during apoptosis

21 January 2018

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Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis

21 January 2018

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Ceramide: an intracellular signal for apoptosis

21 January 2018

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Functions of ceramide in coordinating cellular responses to stress

21 January 2018

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Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation

21 January 2018

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Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

21 January 2018

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Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3.

21 January 2018

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Biochemistry of multidrug resistance mediated by the multidrug transporter

21 January 2018

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The proto-oncogene Bcl-2 and its role in regulating apoptosis

21 January 2018

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Bcl-2 interrupts the ceramide-mediated pathway of cell death.

21 January 2018

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Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

21 January 2018

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Ultrasound-guided fine-needle aspiration biopsy of the thyroid

21 January 2018

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Apoptosis induced by N-hexanoylsphingosine in CHP-100 cells associates with accumulation of endogenous ceramide and is potentiated by inhibition of glucocerebroside synthesis

21 January 2018

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Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation

21 January 2018

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Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis

21 January 2018

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Ceramide induces apoptosis via CPP32 activation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.275.10.7138

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24 September 2017

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