Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. (Q40928334)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490832%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

title

Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490832%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490832%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

Manuel Serrano

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490832%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

author name string

Pantoja C

series ordinal

1

1 reference

24 September 2017

Serrano M

series ordinal

2

1 reference

24 September 2017

language of work or name

English

0 references

publication date

1 September 1999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490832%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490832%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

volume

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490832%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

issue

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490832%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

page(s)

4974-4982

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490832%20AND%20SRC:MED&resulttype=core&format=json

Investigation of the role of G1/S cell cycle mediators in cellular senescence

31 October 2019

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

p14ARF links the tumour suppressors RB and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Radiation-induced cell cycle arrest compromised by p21 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Induction of the growth inhibitor IGF-binding protein 3 by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Cellular senescence in telomerase-expressing Syrian hamster embryo cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Inactivation of p16 in human mammary epithelial cells by CpG island methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Molecular aspects of the relationship between cancer and aging: tumor suppressor activity during cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Splicing into senescence: the curious case of p16 and p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Tumor spectrum analysis in p53-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Expression of p24, a novel p21Waf1/Cip1/Sdi1-related protein, correlates with measurement of the finite proliferative potential of rodent embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Clonal nature of spontaneously immortalized 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Origins of G1 arrest in senescent human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

The cat and mouse games that genes, viruses, and cells play

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Loss of p21CIP1/WAF1 does not recapitulate accelerated malignant conversion caused by p53 loss in experimental skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

p21 is a universal inhibitor of cyclin kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Age-dependent alterations of c-fos and growth regulation in human fibroblasts expressing the HPV16 E6 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Senescence of human fibroblasts induced by oncogenic Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

Increased activity of p53 in senescing fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

7 January 2021

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

7 January 2021

Production of high-titer helper-free retroviruses by transient transfection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

7 January 2021

Genetic analysis of cellular senescence.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202880

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202880

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10490832%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

31 October 2019

1045479827

0 references

1 reference