Toward a molecular understanding of human breast cancer: a hypothesis (Q40920562)

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English	Toward a molecular understanding of human breast cancer: a hypothesis	scientific article

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instance of

scholarly article

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Europe PubMed Central

PubMed publication ID

8518411

retrieved

24 September 2017

review article

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Europe PubMed Central

title

Toward a molecular understanding of human breast cancer: a hypothesis (English)

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Europe PubMed Central

PubMed publication ID

8518411

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24 September 2017

author name string

J W Shay

series ordinal

1

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Europe PubMed Central

PubMed publication ID

8518411

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24 September 2017

W E Wright

series ordinal

2

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Europe PubMed Central

PubMed publication ID

8518411

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24 September 2017

H Werbin

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3

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Europe PubMed Central

PubMed publication ID

8518411

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24 September 2017

language of work or name

English

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publication date

1 January 1993

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Europe PubMed Central

PubMed publication ID

8518411

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24 September 2017

published in

Breast Cancer Research and Treatment

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Europe PubMed Central

PubMed publication ID

8518411

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24 September 2017

volume

25

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Europe PubMed Central

PubMed publication ID

8518411

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24 September 2017

issue

1

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Europe PubMed Central

PubMed publication ID

8518411

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24 September 2017

page(s)

83-94

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Europe PubMed Central

PubMed publication ID

8518411

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24 September 2017

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Cellular aging--clonal senescence. A review (Part I)

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Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus

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Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

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Involvement of wild-type p53 protein in the cell cycle requires nuclear localization

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Efficient immortalization and morphological transformation of human fibroblasts by transfection with SV40 DNA linked to a dominant marker

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Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation

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Origin of Concatemeric T7DNA

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Telomeres shorten during ageing of human fibroblasts

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Fidelity of DNA replication catalysed in vitro on a natural DNA template by the T4 bacteriophage multi-enzyme complex

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12 December 2020

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A role for both RB and p53 in the regulation of human cellular senescence

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12 December 2020

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Ras-induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

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Increased cell division as a cause of human cancer

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12 December 2020

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Are tumours immortal?

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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Selective immortalization of a phenotypically distinct epithelial cell type by microinjection of SV40 DNA into cultured human milk cells.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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inferred from PubMed ID database lookup

Telomere length predicts replicative capacity of human fibroblasts

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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Defining the molecular mechanisms of human cell immortalization

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potential transcriptional activation element in the p53 protein

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PubMed

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12 December 2020

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inferred from PubMed ID database lookup

Establishment and characterization of SV40-transformed human breast epithelial cell lines

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12 December 2020

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Role of adenovirus E1B proteins in transformation: altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein

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PubMed

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Telomere end-replication problem and cell aging

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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inferred from PubMed ID database lookup

On the fidelity of DNA replication. Effect of divalent metal ion activators and deoxyrionucleoside triphosphate pools on in vitro mutagenesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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inferred from PubMed ID database lookup

Telomerases

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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inferred from PubMed ID database lookup

A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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inferred from PubMed ID database lookup

Loss of heterozygosity for the short arm of chromosome 11 (11p15) in human milk epithelial cells immortalized by microinjection of SV40 DNA

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of a potent transcription activating sequence in the p53 protein

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and function of telomeres

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

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From gene to carcinogen: a rapidly evolving field in molecular epidemiology

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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Chemical and physical carcinogenesis: advances and perspectives for the 1990s

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 mutations in human cancers

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomeres, telomerase and senescence

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variability at the telomeres of the human X/Y pseudoautosomal region

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

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Beginning or end? Telomere structure, genetics and biology

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

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Transformation of human cultured fibroblasts with plasmids carrying dominant selection markers and immortalizing potential

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

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Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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Normal oxidative damage to mitochondrial and nuclear DNA is extensive

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

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Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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Definition of a consensus binding site for p53

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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Evidence for the recessive nature of cellular immortality

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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Isolation of simian virus 40-transformed human mammary epithelial stem cell lines that can differentiate to myoepithelial-like cells in culture and in vivo

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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The serial cultivation of human diploid cell strains

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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An ultrastructural study of mitosis and cytokinesis in normal ?resting? human breast

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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Limited and unlimited growth of sv40-transformed cells from human diploid mrc-5 fibroblasts

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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p53 function and dysfunction

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

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Telomeres

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

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The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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inferred from PubMed ID database lookup

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

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Mutagenesis by apurinic/apyrimidinic sites

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immortalization of human mammary epithelial cells by SV40 large T-antigen involves a two step mechanism.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular and molecular advances in elucidating p53 function

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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SV40-INDUCED TRANSFORMATION OF HUMAN DIPLOID CELLS: CRISIS AND RECOVERY

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

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Rate of depurination of native deoxyribonucleic acid

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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Mutations causing hemophilia B: direct estimate of the underlying rates of spontaneous germ-line transitions, transversions, and deletions in a human gene

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

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Telomere loss: mitotic clock or genetic time bomb?

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SV40-transformed human fibroblasts: evidence for cellular aging in pre-crisis cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

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Re-expression of senescent markers in deinduced reversibly immortalized cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

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Oncogenic forms of p53 inhibit p53-regulated gene expression

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomere reduction in human colorectal carcinoma and with ageing

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Telomere positional effects and the regulation of cellular senescence

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8518411

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional simian virus 40 T antigen is expressed in hybrid cells having finite proliferative potential

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of p53 as a sequence-specific DNA-binding protein

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between age and incidence of breast cancer. Population and screening program data

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8518411

retrieved

12 December 2020

based on heuristic

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Identifiers

DOI

10.1007/BF00662404

1 reference

stated in

Europe PubMed Central

PubMed publication ID

8518411

retrieved

24 September 2017

Dimensions Publication ID

1036754005

0 references

PubMed publication ID

8518411

1 reference

stated in

Europe PubMed Central

PubMed publication ID

8518411

retrieved

24 September 2017

 

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