Disease-associated CAG·CTG triplet repeats expand rapidly in non-dividing mouse cells, but cell cycle arrest is insufficient to drive expansion (Q41001212)

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scientific article published on 23 May 2014

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English	Disease-associated CAG·CTG triplet repeats expand rapidly in non-dividing mouse cells, but cell cycle arrest is insufficient to drive expansion	scientific article published on 23 May 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

Disease-associated CAG·CTG triplet repeats expand rapidly in non-dividing mouse cells, but cell cycle arrest is insufficient to drive expansion (English)

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

Mário Gomes-Pereira

object named as

Mário Gomes-Pereira

1

0 references

Darren G Monckton

object named as

Darren G Monckton

6

0 references

author name string

James D Hilley

2

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

Fernando Morales

3

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Europe PubMed Central

PMC publication ID

25 September 2017

Berit Adam

4

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Europe PubMed Central

PMC publication ID

25 September 2017

Helen E James

5

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Europe PubMed Central

PMC publication ID

25 September 2017

publication date

23 May 2014

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Europe PubMed Central

PMC publication ID

25 September 2017

Nucleic Acids Research

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Europe PubMed Central

PMC publication ID

25 September 2017

42

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Europe PubMed Central

PMC publication ID

25 September 2017

11

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

7047-7056

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

copyright license

Creative Commons Attribution 3.0 Unported

5 October 2016

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April 2022 Public Data File from Crossref

copyright status

0 references

Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation

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Transcription elongation and tissue-specific somatic CAG instability

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Msh2-Msh3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions

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Mismatch repair-dependent mutagenesis in nondividing cells.

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Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.

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Conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops

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Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.

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Mechanisms of trinucleotide repeat instability during human development

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A novel approach to investigate tissue-specific trinucleotide repeat instability

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Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset

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DNA instability in postmitotic neurons

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OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

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25 September 2017

Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain

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25 September 2017

CAG*CTG repeat instability in cultured human astrocytes

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25 September 2017

Chemical modifiers of unstable expanded simple sequence repeats: what goes up, could come down

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25 September 2017

Transcription promotes contraction of CAG repeat tracts in human cells

1 reference

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Replication fork dynamics and dynamic mutations: the fork-shift model of repeat instability

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25 September 2017

Pms2 is a genetic enhancer of trinucleotide CAG.CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion

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25 September 2017

Chemically induced increases and decreases in the rate of expansion of a CAG*CTG triplet repeat

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25 September 2017

Replication Inhibitors Modulate Instability of an Expanded Trinucleotide Repeat at the Myotonic Dystrophy Type 1 Disease Locus in Human Cells

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25 September 2017

Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain

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25 September 2017

CTG repeat instability and size variation timing in DNA repair-deficient mice

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Dramatic mutation instability in HD mouse striatum: does polyglutamine load contribute to cell-specific vulnerability in Huntington's disease?

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25 September 2017

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

1 reference

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Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A

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Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts

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Replication-dependent instability at (CTG)•(CAG) repeat hairpins in human cells

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Scaled-down genetic analysis of myotonic dystrophy type 1 and type 2.

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Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells.

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Somatic instability of the CTG repeat in mice transgenic for the myotonic dystrophy region is age dependent but not correlated to the relative intertissue transcription levels and proliferative capacities.

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Somatic instability of the expanded CTG triplet repeat in myotonic dystrophy type 1 is a heritable quantitative trait and modifier of disease severity

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High levels of somatic DNA diversity at the myotonic dystrophy type 1 locus are driven by ultra-frequent expansion and contraction mutations.

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Huntington's and myotonic dystrophy hESCs: down-regulated trinucleotide repeat instability and mismatch repair machinery expression upon differentiation

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Msh3 is a limiting factor in the formation of intergenerational CTG expansions in DM1 transgenic mice.

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19 August 2018

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

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19 August 2018

Somatic mosaicism, germline expansions, germline reversions and intergenerational reductions in myotonic dystrophy males: small pool PCR analyses

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21 January 2018

Hypermutable myotonic dystrophy CTG repeats in transgenic mice

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Simple repeat DNA is not replicated simply

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12 December 2020

based on heuristic

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Destabilization of CAG trinucleotide repeat tracts by mismatch repair mutations in yeast

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https://pubmed.ncbi.nlm.nih.gov/24860168

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Small slipped register genetic instabilities in Escherichia coli in triplet repeat sequences associated with hereditary neurological diseases

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based on heuristic

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Identifiers

10.1093/NAR/GKU285

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

ResearchGate publication ID

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