The "clonal selection hypothesis" and current concepts of B cell tolerance (Q41113352)

26 September 2017

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title

The "clonal selection hypothesis" and current concepts of B cell tolerance (English)

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26 September 2017

Klinman NR

1

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26 September 2017

language of work or name

English

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publication date

1 September 1996

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26 September 2017

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26 September 2017

volume

5

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26 September 2017

issue

3

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26 September 2017

page(s)

189-195

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Self tolerance in the B-cell repertoire.

26 September 2017

cites work

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Mutation drift and repertoire shift in the maturation of the immune response

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Carrier-Determined Tolerance in Various Strains of Mice: The Role of Isogenic IgG in the Induction of Hapten Specific Tolerance

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A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively

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Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance

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Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice

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Developmentally controlled selection of antibody genes: Characterization of individual VH7183 genes and evidence for stage-specific somatic diversification

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A role for immunoglobulin D: interference with tolerance induction

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Transitional B cells are the target of negative selection in the B cell compartment

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Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin

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The autoantigenic response to rabbit cytochrome c

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Expression and selection of murine antibody repertoires

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Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

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Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro

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Genetic and temporal control of neonatal antibody expression

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Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

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Transgenic mice and analysis of B-cell tolerance

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Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

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7 January 2021

Breakdown of self-tolerance in anergic B lymphocytes.

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7 January 2021

Hapten-specific tolerance in mice. II. Adoptive transfer studies and evidence for unresponsiveness in the B cells

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A natural model of immunologic tolerance. Tolerance to murine C5 is mediated by T cells, and antigen is required to maintain unresponsiveness

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Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

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Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

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7 January 2021

Intraclonal generation of antibody mutants in germinal centres

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7 January 2021

T cell receptor antagonists and partial agonists

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7 January 2021

THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION

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7 January 2021

Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates

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7 January 2021

The mechanism of antigenic stimulation of primary and secondary clonal precursor cells

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7 January 2021

In vitro analysis of the generation and propagation of memory B cells

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7 January 2021

The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice

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7 January 2021

Overlap stimulation of primary and secondary B cells by cross-reacting determinants

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7 January 2021

2,4-Dinitrophenyl receptors on mouse thymus and spleen cells

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7 January 2021

Suppression of immunoglobulin class synthesis in mice. I. Effects of treatment with antibody to -chain

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Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations.

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7 January 2021

Somatic mutation in anti-phosphorylcholine antibodies

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7 January 2021

Evolution of antibody variable region structure during the immune response

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7 January 2021

In vitro tolerance induction of neonatal murine B cells

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7 January 2021

In vitro tolerance induction of neonatal murine B cells as a probe for the study of B-cell diversification

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7 January 2021

Murine Models of Tolerance Induction in Developing and Mature B Cells

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7 January 2021

Spleen cells from animals tolerant to a thymus-dependent antigen can be activated by lipopolysaccharide to synthesize antibodies against the tolerogen

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7 January 2021

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

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7 January 2021

De novo germinal center formation

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7 January 2021

Cellular mechanisms of immunologic tolerance

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7 January 2021

Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen

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7 January 2021

A transgenic model of autoimmune hemolytic anemia

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7 January 2021

A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible

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7 January 2021

Clonal anergy: the universally anergic B lymphocyte

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7 January 2021

Frequency of hapten-specific B cells in neonatal and adult murine spleens

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7 January 2021

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

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7 January 2021

Structural patterns in anti-DNA antibodies from MRL/lpr mice

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7 January 2021

B lymphocytes may escape tolerance by revising their antigen receptors

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7 January 2021

Evolutionary and somatic selection of the antibody repertoire in the mouse.

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7 January 2021

Peripheral deletion of self-reactive B cells

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https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980314-3

7 January 2021

Multiple Pathways of B Lymphocyte Tolerance

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7 January 2021

Antigen analogs/MHC complexes as specific T cell receptor antagonists

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7 January 2021

Antigen-induced B-cell death and elimination during germinal-centre immune responses

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7 January 2021

Late acquisition of a germ line antibody specificity

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7 January 2021

Induction of an immune response to a self antigen

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7 January 2021

Ontogeny of B-lymphocyte function. III. In vivo and in vitro studies on the ease of tolerance induction in B lymphocytes from fetal, neonatal, and adult mice

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7 January 2021

Allergy and Immunology

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7 January 2021

Tolerance as an active process

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7 January 2021

In vitro model for natural tolerance to self-antigens. Inhibition of the development of surface-immunoglobulin-negative lymphocytes into T-dependent responsive B cells by antigen

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7 January 2021

Receptor editing in self-reactive bone marrow B cells

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7 January 2021

Analysis of Autoimmunity through Experimental Models of Thyroiditis and Allergic Encephalomyelitis

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7 January 2021

10.1016/S1074-7613(00)80314-3

Identifiers

DOI

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26 September 2017

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