First-in-human study assessing safety, tolerability and pharmacokinetics of BI 409306, a selective phosphodiesterase 9A inhibitor, in healthy males (Q41444802)

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scientific article published on 4 July 2016

Language	Label	Description	Also known as
English	First-in-human study assessing safety, tolerability and pharmacokinetics of BI 409306, a selective phosphodiesterase 9A inhibitor, in healthy males	scientific article published on 4 July 2016

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

First-in-human study assessing safety, tolerability and pharmacokinetics of BI 409306, a selective phosphodiesterase 9A inhibitor, in healthy males (English)

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

author name string

Viktoria Moschetti

1

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Katja Boland

2

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Ulrich Feifel

3

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Anja Hoch

4

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Heike Zimdahl-Gelling

5

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

Michael Sand

6

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

language of work or name

0 references

publication date

4 July 2016

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Europe PubMed Central

PMC publication ID

30 September 2017

British Journal of Clinical Pharmacology

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Europe PubMed Central

PMC publication ID

30 September 2017

82

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Europe PubMed Central

PMC publication ID

30 September 2017

5

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

1315-1324

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5061793

1 October 2017

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive funct

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5061793

1 October 2017

Glutamate receptors in preclinical research on Alzheimer's disease: update on recent advances.

1 reference

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1 October 2017

Glutamate signaling in the pathophysiology and therapy of schizophrenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5061793

1 October 2017

The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents

1 reference

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1 October 2017

The late maintenance of hippocampal LTP: requirements, phases, 'synaptic tagging', 'late-associativity' and implications

1 reference

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1 October 2017

Plasticity in the human central nervous system

1 reference

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1 October 2017

A synaptic model of memory: long-term potentiation in the hippocampus

1 reference

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1 October 2017

A multicenter, double-blind, placebo-controlled trial of the PDE9A inhibitor, PF-04447943, in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5061793

19 August 2018

PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5061793

19 August 2018

Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5061793

19 August 2018

Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5061793

19 August 2018

Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5061793

19 August 2018

mRNA expression patterns of the cGMP‐hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5061793

19 August 2018

Identifiers

10.1111/BCP.13060

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

30 September 2017

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