Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition (Q41707732)

7 October 2017

Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition (English)

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7 October 2017

7

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7 October 2017

Johannes Kluwe

1

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7 October 2017

Jean-Philippe Pradere

2

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7 October 2017

Geum-Youn Gwak

3

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7 October 2017

Ali Mencin

4

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7 October 2017

Samuele De Minicis

5

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7 October 2017

Christoph H Osterreicher

6

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7 October 2017

Ramon Bataller

8

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7 October 2017

Robert F Schwabe

9

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7 October 2017

language of work or name

English

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publication date

24 September 2009

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7 October 2017

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7 October 2017

138

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7 October 2017

1

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7 October 2017

347-359

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describes a project that uses

7 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2988578/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice

6 June 2018

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Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

6 June 2018

1 reference

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Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

6 June 2018

1 reference

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Divergent transforming growth factor-beta signaling in hepatic stellate cells after liver injury: functional effects on ECE-1 regulation

6 June 2018

1 reference

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Mechanisms of hepatic fibrogenesis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1

6 June 2018

1 reference

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Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

6 June 2018

1 reference

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TLR4 enhances TGF-beta signaling and hepatic fibrosis

6 June 2018

1 reference

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Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

6 June 2018

1 reference

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Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases

6 June 2018

1 reference

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Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

6 June 2018

1 reference

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Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway

6 June 2018

1 reference

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IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.

6 June 2018

1 reference

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Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury

6 June 2018

1 reference

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6 June 2018

1 reference

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Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation

6 June 2018

1 reference

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NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis

6 June 2018

1 reference

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Regulation of ERK/JNK/p70S6K in two rat models of liver injury and fibrosis

6 June 2018

1 reference

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Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing.

6 June 2018

1 reference

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Regulation and function of the JNK subgroup of MAP kinases

6 June 2018

1 reference

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

6 June 2018

1 reference

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Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis

6 June 2018

1 reference

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c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

JNK1 but not JNK2 promotes the development of steatohepatitis in mice

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

Role of Jun N-terminal Kinase (JNK) signaling in the wound healing and regeneration of a Drosophila melanogaster wing imaginal disc.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

JNK mediates hepatic ischemia reperfusion injury

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

JNK signaling pathway required for wound healing in regenerating Drosophila wing imaginal discs

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988578

Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19782079

12 December 2020

inferred from PubMed ID database lookup

The JNK signal transduction pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19782079

12 December 2020

inferred from PubMed ID database lookup

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19782079

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1053/J.GASTRO.2009.09.015

1 reference

7 October 2017

1 reference

7 October 2017

PubMed publication ID

19782079

1 reference