RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion (Q41733269)

8 October 2017

1 reference

title

RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion (English)

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8 October 2017

2

Südhof TC

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8 October 2017

Geppert M

1

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8 October 2017

publication date

1 January 1998

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Annual Review of Neuroscience

8 October 2017

number of pages

21

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published in

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8 October 2017

volume

21

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8 October 2017

page(s)

75-95

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Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion

8 October 2017

cites work

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C

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Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins

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https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

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Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins

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SNAP receptors implicated in vesicle targeting and fusion

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11 October 2022

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Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Synaptic vesicles and exocytosis

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Distinct Ca(2+)-dependent properties of the first and second C2-domains of synaptotagmin I.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

A post-docking role for synaptobrevin in synaptic vesicle fusion

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Complexins: cytosolic proteins that regulate SNAP receptor function

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11 October 2022

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Nonuniform probability of glutamate release at a hippocampal synapse

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Tetanus and botulinum neurotoxins are zinc proteases specific for components of the neuroexocytosis apparatus

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Specificity and regulation of a synaptic vesicle docking complex

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Overexpression of epsilon-protein kinase C enhances nerve growth factor-induced phosphorylation of mitogen-activated protein kinases and neurite outgrowth

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Distinct Ca2+ and Sr2+ binding properties of synaptotagmins. Definition of candidate Ca2+ sensors for the fast and slow components of neurotransmitter release

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Synaptic transmission persists in synaptotagmin mutants of Drosophila

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

The probability of transmitter release at a mammalian central synapse.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Synaptotagmins: C2-domain proteins that regulate membrane traffic

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Rab proteins and the road maps for intracellular transport

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

PDZs and receptor/channel clustering: rounding up the latest suspects

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

n-Sec1: a neural-specific syntaxin-binding protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Molecular dissection of the secretory pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

The GTPase superfamily: conserved structure and molecular mechanism

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

The synaptic vesicle cycle: a cascade of protein-protein interactions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Interaction of Sec4 with GDI proteins from bovine brain, Drosophila melanogaster and Saccharomyces cerevisiae. Conservation of GDI membrane dissociation activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

The role of Rab3A in neurotransmitter release

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Functional properties of multiple synaptotagmins in brain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

A role for synaptotagmin (p65) in regulated exocytosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Mechanisms of intracellular protein transport

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Two components of transmitter release at a central synapse

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Phosphorylation of rabphilin-3A by Ca2+/calmodulin- and cAMP-dependent protein kinases in vitro.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Calcium dependence of the rate of exocytosis in a synaptic terminal

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

GPI-anchored influenza hemagglutinin induces hemifusion to both red blood cell and planar bilayer membranes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.NEURO.21.1.75

Identifiers

DOI

10.1146/ANNUREV.NEURO.21.1.75

1 reference

8 October 2017

1 reference