Therapeutic intervention and signaling (Q41751027)

8 October 2017

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title

Therapeutic intervention and signaling (English)

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8 October 2017

Heimbrook DC

1

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8 October 2017

Oliff A

series ordinal

2

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8 October 2017

language of work or name

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1 April 1998

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Current Opinion in Cell Biology

8 October 2017

published in

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8 October 2017

volume

10

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8 October 2017

issue

2

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8 October 2017

page(s)

284-288

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Function and regulation of ras.

8 October 2017

cites work

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7 January 2021

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

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7 January 2021

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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7 January 2021

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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7 January 2021

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

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7 January 2021

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

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7 January 2021

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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7 January 2021

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

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7 January 2021

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein

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7 January 2021

Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I

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7 January 2021

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

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7 January 2021

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

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7 January 2021

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

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7 January 2021

Inhibition of anchorage-independent growth of ras-transformed cells on polyHEMA surface by antisense oligodeoxynucleotides directed against K-ras

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7 January 2021

Specific hammerhead ribozyme-mediated cleavage of mutant N-ras mRNA in vitro and ex vivo. Oligoribonucleotides as therapeutic agents

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7 January 2021

Multiple Ras functions can contribute to mammalian cell transformation

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7 January 2021

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

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7 January 2021

A role for Rho in Ras transformation

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7 January 2021

An essential role for Rac in Ras transformation

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7 January 2021

Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

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7 January 2021

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Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

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7 January 2021

A synthetic inhibitor of the mitogen-activated protein kinase cascade

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7 January 2021

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

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7 January 2021

Phosphoinositide 3-kinases: a conserved family of signal transducers

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7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

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7 January 2021

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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7 January 2021

PI3K: downstream AKTion blocks apoptosis

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7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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7 January 2021

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

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7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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7 January 2021

PtdIns(3,4,5)P3 gets its message across

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7 January 2021

The proto-oncogene Bcl-2 and its role in regulating apoptosis

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7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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7 January 2021

Regulation of neuronal survival by the serine-threonine protein kinase Akt

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7 January 2021

10.1016/S0955-0674(98)80152-X

Identifiers

DOI

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8 October 2017

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